Browsing by Title
Now showing items 13820-13839 of 17439
-
(2019-03-27)Department: ChemistryThe cell is regulated by a vast network of dynamic protein interactions that facilitate various sub-cellular functions. To systematically monitor and characterize these transient and rapidly changing protein interactions, ...
-
(2013-12-04)Department: Biomedical EngineeringBiodegradable tissue engineering scaffolds are commonly fabricated from poly(lactide-co-glycolide) (PLGA) or similar polyesters that degrade by hydrolysis. PLGA hydrolysis generates acidic byproducts that trigger an ...
-
(2021-11-15)Department: ChemistryThe introduction of ferroelectric properties in quantum dots through cation exchange multiplies their already ever-growing list of applications, elevating their utility in industry. We report the appearance of ferroelectric ...
-
(2018-05-16)Department: ChemistryCHEMISTRY Synthesis of Four Diastereomeric Linoleic Triols and Development of a Large Scale Convergent Approach to Apoptolidinone C Robert Woods Davis Dissertation under the direction of Professor Gary A. Sulikowski The ...
-
(2017-12-08)Department: ChemistryRecent progress in nanotechnology has enabled rapid expansion at the interface of polymeric systems and biomedicine such that synthetic nanocarriers can be capable of entrapment and tunable releases of chemotherapeutics, ...
-
(2014-11-06)Department: PharmacologyPhospholipase D (PLD) catalyzes the production of the lipid second messenger phosphatidic acid (PtdOH). PLD expression and/or enzymatic activity are both elevated in a variety of human cancers. Inhibition of PLD enzymatic ...
-
(2021-05-22)Department: Interdisciplinary Materials ScienceFunctional polymers are macromolecules with unique properties that depend on the presence of specific chemical moieties within their structure. Such polymer chains can have useful intrinsic properties (e.g. specific ...
-
(2005-08-12)Department: Computer Scienceto be entered
-
(2021-03-23)Department: Computer ScienceCochlear implants are surgically implanted neural prosthetic devices that are used to treat severe hearing loss. These devices are programmed post-implantation, and estimations of patient-specific neural activation patterns ...
-
(2023-01-09)Department: ChemistrySince the discovery that nonsteroidal anti-inflammatory drugs (NSAIDs) prevent pain, swelling, and inflammation by inhibiting the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), there has been interest in ...
-
(2013-04-15)Department: Chemical and Physical BiologyThe topological structure of DNA is regulated by ubiquitous enzymes called topoisomerases. Type II topoisomerases resolve supercoils and remove knots and tangles from the genetic material by generating transient breaks in ...
-
(2022-06-09)Department: Computer ScienceThe past decade has witnessed a dramatic rise in the adoption of electronic medical record (EMR) systems. EMR data assists in the development and evaluation of clinical information systems, supports novel biomedical research, ...
-
(2021-05-10)Department: Cancer BiologyClear cell renal cell carcinoma (ccRCC) is the most common kidney tumor, and its incidence continues to rise. Elucidation of the molecular biology and the tumor microenvironment (TME) have revolutionized the treatment ...
-
(2014-03-21)Department: ChemistryFeglymycin is a tridecapeptide that has been shown to act as an inhibitor of the formation of HIV syncytia as well as the cell-to-cell transmission of the virus. The natural product contains thirteen amino acid residues, ...
-
(2016-04-07)Department: ChemistryThe rational design of hybrid nanoparticles is a powerful tool in harnessing nanoscale properties of several different materials in a single whole. The first portion of this work describes the synthesis of dual-plasmonic ...
-
(2009-10-20)Department: ChemistryAs a selective apoptosis inducer, apoptolidin A was isolated from Nocardiopsis Sp. by Japanese chemists in 1997. Khosla and coworkers have demonstrated that apoptolidin A could inhibit the activity of mitochondrial F0F1-ATP ...
-
(2021-05-05)Department: ChemistryNatural products have a long history of serving as therapeutic leads (e.g. taxol and compactin) and biological tools (e.g. rapamycin and oligomycin). Bielschowskysin is a rare and structurally complex marine diterpene, ...
-
Synthetic Studies on Hemiketal E2 and 5-Hydroxy Prostaglandin E2 Novel Arachidonic Acid Metabolites (2021-10-06)Department: ChemistryThe metabolites of arachidonic acid have long been studied for their intimate role in the human body inflammatory pathway. Inflammation is the body’s natural defense against foreign pathogens and maintains the body’s ability ...
-
(2021-06-11)Department: ChemistryProgress toward the total synthesis of the manzamine alkaloid xestocyclamine A is described. Due to the architecturally interesting structures and biological activity of the manzamine alkaloids, xestocyclamine A remains ...
-
(Vanderbilt University, 2010)Abstract: Syphilis has re-emerged as a global public health issue. In lesser developed countries, millions of people are contracting the disease, which can be fatal without access to proper treatment. In developed countries, ...