Browsing by Department "Biological Sciences"
Now showing items 21-40 of 157
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(2005-08-11)Department: Biological SciencesPSF (PTB-associated splicing factor) has been implicated in both early and late steps of pre-mRNA splicing as well as multiple nuclear events including transcription regulation, nuclear RNA retention/export, topoisomerase ...
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(2013-07-18)Department: Biological SciencesCells that are migrating in a chemical gradient display a polarized distribution of signaling and cytoskeletal components. We have investigated the mechanism of polarity establishment by using the model system Dictyostelium ...
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(2012-06-11)Department: Biological SciencesTelomeres are protective protein/DNA complexes that cap the ends of linear chromosomes. The repetitive, TG-rich telomeric sequences are elongated by the telomerase ribonucleoprotein. In Saccharomyces cerevisiae, the ...
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(2008-10-22)Department: Biological SciencesOne of the greatest factors contributing to the worldwide decline in biodiversity is habitat destruction leading to the loss and fragmentation of populations of many species. Knowledge of the genetic and demographic factors ...
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(2011-09-02)Department: Biological SciencesThis project explores the synthesis of heterogeneous G1-3T yeast telomere sequences by the enzyme telomerase. I demonstrate that a mutant in the essential N-terminal TEN domain of Est2p (telomerase reverse transciptase), ...
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(2020-02-17)Department: Biological SciencesIn the nervous system, Wnts act as potent regulators of synaptic connectivity, architecture, neurotransmission strength and activity-dependent plasticity. As the founding Wnt, Drosophila Wingless (Wg) has key roles at the ...
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(2024-02-26)Department: Biological SciencesMy thesis work examines how coronaviruses hijack host cell proteins and stress response pathways during infection. Coronaviruses encode sixteen nonstructural proteins (nsps), which interact with host proteins to modulate ...
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(2019-04-16)Department: Biological SciencesAnimal body plans, olfaction, immune response, and, neuronal connectivity, among many others, traits that in addition to being highly polymorphic, are driven by clusters of tandemly duplicated genes (CTDG). CTDGs are not ...
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(2010-12-21)Department: Biological SciencesCircadian rhythms are intrinsic biological rhythms that have a period close to 24 hours. Prokaryotic cyanobacteria are the simplest organisms that show robust circadian rhythms, and are the only organisms that have a ...
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(2011-04-29)Department: Biological SciencesThe ability of SV40 to activate the DNA damage response raises the question of whether the virus also induces DNA damage. Broken nuclear DNA in SV40-infected BSC40 cells could be detected at 5 hours post infection (hpi) ...
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(2019-04-08)Department: Biological SciencesOver the years, periodic innovations in fluorescence microscopic technologies have afforded researchers a more sophisticated understanding of the inner workings of the cell. These methods are valuable but drawbacks include ...
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(2019-03-19)Department: Biological SciencesThe Drosophila Giant Fiber (GF) circuit is a highly tractable set of neurons driving rapid escape behavior. The work presented here takes advantage of the large size and accessibility of these central neurons to study ...
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(2007-12-04)Department: Biological SciencesIn recent years it has become apparent that microRNAs (miRNAs) are common feature of eukaryotic genomes. The functional products of these non-canonical genes are small, ~22nt RNAs that negatively regulate translation. ...
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(2013-09-06)Department: Biological SciencesThe effects of DNA damage signaling on the DNA replication of the polyomavirus SV40 are examined in this dissertation. Infection of monkey cells with SV40 results in large amounts of cellular DNA damage signaling through ...
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(2022-06-20)Department: Biological SciencesDNA replication is a fundamental challenge of life. In order to proliferate, every organism must be able to replicate and divide its DNA into daughter cells. Defects in DNA replication can cause in mutations that can result ...
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(2010-11-30)Department: Biological SciencesDNA polymerase ¦Á-primase (pol-prim) plays a central role in eukaryotic DNA replication, initiating synthesis on both the leading and lagging strand DNA templates. Pol-prim consists of a primase heterodimer that synthesizes ...
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(2022-12-20)Department: Biological SciencesModern-day birdsong is exceptionally diverse, with each of over 4,000 extant songbird species effectively singing a unique and recognizable song. Since song is a learned behavior, its evolutionary dynamics may be complex ...
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(2010-05-10)Department: Biological SciencesEcological speciation is defined as the process by which reproductive isolation arises between populations as a result of ecologically based divergent selection between environments. Selection is ecological when individual ...
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(2015-07-09)Department: Biological SciencesInitiation of DNA Replication is a highly regulated process and is characterized by the conversion of inactive Mcm2-7 double hexamer around dsDNA to an active helicase consisting of Mcm2-7 single hexamer which encircles ...
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Essential Roles of Convergence and Extension Gastrulation Movements in Zebrafish Somite Development (2007-02-27)Department: Biological SciencesDuring vertebrate gastrulation, massive cell movements shape the basic body plan. Key components of gastrulation are convergence and extension (C&E) movements, which narrow and lengthen the embryonic tissues, respectively. ...