Browsing by Title
Now showing items 3671-3690 of 17421
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(2015-07-01)Department: Biomedical EngineeringCurrent treatment for moderate and severe mitral regurgitation (MR), due to degenerative mitral valve (MV) disease, is open-chest surgical repair or replacement, as there are no known pharmacologic therapies that directly ...
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(2014-12-02)Department: Interdisciplinary Studies: Environmental ManagementThe 2013 Report Card for the Nation’s Infrastructure, published by the American Society of Civil Engineers, estimates that more than 10% of the over 607,000 bridges in the United States are structurally deficient. Engendering ...
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(2013-08-04)Department: EpidemiologyLung cancer is deadly, killing more people than breast, colon and prostate cancer combined. Surgeons evaluating patients for lung cancer face a dilemma: to operate and subject the individual to operation associated mortality ...
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(2007-04-14)Department: Biomedical EngineeringHepatic fibrosis is a progressive disease in which progression is correlated to liver mechanical properties. This correlation may be used to assess the state of the disease, and hence methods to determine the elastic ...
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(2021-09-10)Department: NeuroscienceSepsis is a life-threatening illness characterized by acute organ dysfunction including encephalopathy that clinically manifests as delirium. Survivors experience persistent cognitive deficits that indicate lasting ...
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(2006-02-06)Department: Biomedical EngineeringSelective targeting of damaged or diseased cells is a concept with great potential to revolutionize the efficacy of systemically administered agents. Successful targeting preferentially delivers imaging agents and/or ...
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Development of a new model-based radiation dose calculation algorithm for kilovoltage energy x-rays (2013-07-15)Department: PhysicsKilovoltage energy x-rays have long been used in medicine. With the rapid increase in use of x-ray imaging for diagnostics and for imaging guidance during radiotherapy there is an increased interest in determining the ...
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(2021-12-06)Department: Biomedical EngineeringLow cardiac output syndrome (LCOS) describes a collection of clinical symptoms that can arise in pediatric patients after surgical correction of a congenital heart defect (CHD). The consequences of low cardiac output states ...
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(2011-09-13)Department: NeuroscienceExpansion in the glutamine encoding CAG triplet-repeat in the Huntingtin (HTT) gene causes Huntington’s disease (HD). The susceptibility, age of onset, and severity of HD is modified by ill-defined genetic and/or environmental ...
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(2007-08-02)Department: Biomedical EngineeringT cells occupy a central role in cell-mediated immunity and as such, deciphering the signaling events that govern T cell activity is critical in fully understanding the adaptive immune response. Current immunologic ...
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(2009-09-02)Department: Biomedical EngineeringLimitations of commercial RNA extraction kits make them inappropriate for use in a clinical setting. This project develops and evaluates a point-of-care process for simple and rapid extraction of RNA from clinical samples. ...
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(2020-11-17)Department: PhysicsPHYSICS Development of a scintillation-based CMOS Quantitative Autoradiography imager for Safeguard Applications Ardelia Michelle Clarke Dissertation under the direction of Professor Todd Peterson This dissertation ...
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(2014-03-17)Department: Biomedical EngineeringNucleic acid extraction is a significant roadblock to the widespread use of molecular detection strategies such as PCR in resource-limited settings. This thesis explores the potential to simplify nucleic acid extractions ...
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(2012-04-05)Department: Biomedical EngineeringMitral valve prolapse is one subtype of mitral valve disease and is characterized by enlarged leaflets that are often thickened and have disrupted collagen architecture. The increased surface area of leaflets with mitral ...
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(2013-12-04)Department: Biomedical EngineeringAdvantages of high-purity germanium (HPGe) detectors over traditional scintillator detectors include excellent energy resolution, approximately 1% at 140 keV, which allows for better scatter rejection and simple multi-isotope ...
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(2018-03-27)Department: ChemistryThe aim of this research was to develop strategies to advance ion mobility-mass spectrometry (IM-MS) studies via both the development of a novel, spatially multiplexed instrument and the conformational analyses of biomolecules, ...
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(2012-12-14)Department: ChemistryI describe a methodology for preparing and using a standard target for calibrating, laser alignment and focusing of MALDI imaging mass spectrometry instruments. The target is constructed by simple detachment patterning ...
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(2014-07-17)Department: ChemistryCuInS2 is a ternary semiconductor material with potential alternative energy applications in photovoltaic devices and in systems designed for photocatalytic water reduction. To date, the majority of research into CuInS2 ...
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(2017-08-07)Department: Biomedical EngineeringHemodialysis is the primary lifeline for nearly half a million Americans with end-stage renal disease (ESRD). Unfortunately, 40 – 60% of these access sites occlude and fail within the first year. This causes significant ...
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(2020-03-25)Department: Environmental EngineeringThe development of a flexible methodology to comprehensively identify the hazards, and determine the most significant risks associated with the operation of advanced nuclear reactor designs, is required in order to ...