Browsing by Title
Now showing items 6088-6107 of 17411
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(2008-04-15)Department: NeuroscienceNeuroscience Dissertation under the direction of Professor Randy D. Blakely This dissertation is focused on the function and regulation of the choline transporter (CHT). I used CHT heterozygous and homozygous mice, and ...
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(2017-11-21)Department: EpidemiologyPrevious pharmacogenetics studies of 5-fluorouracil (5-FU) have focused on coding variants, and only four of these variants showed consistent association, which explained a small fraction of the heritability of 5-FU-associated ...
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(2008-03-05)Department: Cancer BiologyThere is a significant genetic component to prostate cancer (PrCa) risk. Multiple epidemiologic and linkage studies suggest X-linked heritability. Located at chromosome Xq27-28, HPCX has been identified as a PrCa susceptibility ...
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(2019-05-08)Department: Microbiology and ImmunologyAdverse reactions to drugs are a threat to individual safety and quality of life. Two of the severest reactions, Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and Drug Reaction with Eosinophilia and Systemic ...
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(2014-10-29)Department: NeuroscienceEpilepsy is a common neurological disease characterized by an enduring predisposition to generate seizures. Although multiple factors contribute to epilepsy, the majority of cases are genetic in origin. Variable expressivity ...
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(2016-11-03)Department: PharmacologyThe application of genome science to inherited heart disease requires accurate genetic evaluation and understanding of physiologic resulting from genetic variation. Using a Long QT syndrome phenotype that is very suggestive ...
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(2014-08-28)Department: Human GeneticsCardiovascular disease (CVD) is an inclusive term encompassing several disorders of the circulatory system that together account for the majority of global non-communicable disease (NCD) mortality. Major thrombotic events, ...
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(2013-07-17)Department: Human GeneticsPreterm birth (PTB), defined as live birth before 37 weeks’ completed gestation, is the leading cause of infant mortality worldwide. Despite this major public health concern, little is known about the pathogenesis of PTB. ...
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(2015-04-13)Department: Human GeneticsOne third of the world’s population has been infected with Mycobacterium tuberculosis (MTB). Most of those exposed develop an asymptomatic latent infection. In the absence of co-morbidities, only 5-10% of people progress ...
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(2015-04-05)Department: Medicine, Health, and SocietyThe prevalence of combat-induced male genital injury suffered in modern warfare is at historic levels, and yet it remains as an underdeveloped area of military discourse, rendering it into an invisible phenomenon. Although ...
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(2022-07-11)Department: EpidemiologyTo date, genome-wide association studies (GWAS) have identified common genetic variants at approximately 200 loci for breast cancer risk. GWAS have been predominately conducted among women of European ancestry, and the ...
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(Nature Communications, 2020-01-09)Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded ...
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(Nature Communications, 2019-09-11)Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we ...
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(American Journal of Respiratory and Critical Care Medicine, 2020-03-01)
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(Translational Psychiatry, 2020-02-03)Motivated by observational studies that report associations between schizophrenia and traits, such as poor diet, increased body mass index and metabolic disease, we investigated the genetic contribution to dietary intake ...
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(2021-01-06)Department: Cell & Developmental BiologyEpithelial cells possess intrinsic mechanisms to maintain an appropriate cell density for normal tissue morphogenesis and homeostasis. Defects in such mechanisms likely contribute to hyperplasia and cancer initiation. To ...
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(2018-08-28)Department: Biomedical InformaticsNon-coding gene regulatory enhancers are essential to transcription in mammalian cells. As a result, a large variety of experimental and computational strategies have been developed to identify cis-regulatory enhancer ...
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(JOURNAL OF BIOMEDICAL SCIENCE, 2019-07-03)BackgroundHuman enteroviruses contain over 100 serotypes. We have routinely conducted enterovirus surveillance in northern Taiwan; but about 10% of isolates could not be serotyped using traditional assays. Next-generation ...
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(2005-11-07)Department: Cell and Developmental BiologyProper function of the brain requires that neurons adopt different morphologies and connections. In the nematode <i>C. elegans</i>, VA and VB motor neurons arise from a common precursor cell but adopt different morphologies ...
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(Garland Pub., 1823-09)