Browsing by Title
Now showing items 7104-7123 of 17687
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(2010-02-09)Department: NeuroscienceTranscripts encoding 5HT2C receptors are modified posttranscriptionally by RNA editing, generating up to 24 protein isoforms. In recombinant cells, the fully edited isoform, 5HT2C-VGV, exhibits blunted G-protein coupling ...
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(2014-07-01)Department: Biomedical EngineeringHER2-amplified (HER2+) breast cancers are treated with the anti-HER2 monoclonal antibody trastuzumab. Although trastuzumab reduces production of the angiogenic factor VEGF in HER2+ tumors, the acute and sustained effects ...
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(2006-12-01)Department: Biomedical EngineeringThe islets of Langerhans play a central role in maintenance of glucose homeostasis. Apoptosis of the insulin-producing beta cells of the islet leads to diabetes mellitus. The ability to non-invasively image or assess the ...
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(SCIENTIFIC REPORTS, 2019-07-02)Imaging apoptosis could provide an early and specific means to monitor tumor responses to treatment. To date, despite numerous attempts to develop molecular imaging approaches, there is still no widely-accepted and reliable ...
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(2017-11-27)Department: Biomedical EngineeringObjective: The purpose of this investigation is to test whether a poroelastic model with enhanced structure could capture in vivo interstitial pressure dynamics in a brain undergoing mock surgical loads. Methods: Using ...
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In Vivo Raman Spectroscopic Analysis of HSP70 and Laser Preconditioning in Murine Incisional Wounds (2010-04-16)Department: Biomedical EngineeringLaser preconditioning augments incisional wound healing by reducing scar tissue and increasing maximum tensile load of the healed wound. Under the hypothesis that HSP70 plays an active role in reported results and to better ...
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(2018-08-30)Department: Biomedical EngineeringBone grafts are scaffold constructs required for the treatment of bone diseases and fracture when a defect is above a critical size to heal naturally. Bone tissue engineering approaches aim to recapitulate the physical, ...
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(2021-03-22)Department: Mechanical EngineeringThis research investigates the effectiveness of various in-process cooling (IPC) sources in the friction stir extrusion (FSE) process to improve the strength and hardness performance of the weld joints. Four cooling sources ...
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(2012-04-16)Department: Teaching and LearningThis study aimed to investigate the influences that impact in-service teachers of ELLs’ professional development decisions. In this dissertation, I followed the work of four in-service ELL teachers in two different school ...
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(2007-04-09)Department: PsychologyConsiderable research evidence confirms that parental involvement is associated with positive school outcomes for children; it also confirms that teachers’ invitations are a strong predictor and motivator of parents’ ...
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(Case Western Reserve Journal of International Law, 2012)The constitutional infirmity of the War Powers Resolution has been uniformly demonstrated by more than four decades of bipartisan experience. The Resolution manifestly fails to eliminate the healthy interbranch tensions ...
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(2011-07-24)Department: PsychologyAlthough inappropriate or excessive guilt is a symptom of depression, no measures exist that directly and effectively assess the construct. A wide range of measures assess guilt but there are inconsistencies in how guilt ...
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(Vanderbilt University, 2011)We investigate how increases in publication delays have affected the life-cycle of publications of recent Ph.D. graduates in economics. We construct a panel dataset of 14,271 individuals who were awarded Ph.D.s between ...
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(Vanderbilt University, 2011)The Portuguese and Dutch merchant empires had a similar geographic distribution with outposts all around the Indian Ocean, which they controlled and manned. Both empires faced the same problem of monitoring their agents ...
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(2005-04-24)Department: Civil EngineeringHighway incidents are a major source of traffic congestion, the paramount operational problem on urban freeways. Considerable national attention has been directed towards the effective management of traffic incidents to ...
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(2013-04-15)Department: Civil and Enviromental EngineeringThis research investigates a quantitative methodology for the inclusion of fatigue, induced by sleep deprivation, in human reliability analysis (HRA). A statistical approach is developed for the use of empirical data in ...
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(2023-07-18)Department: Medicine, Health & SocietyMinority representation in clinical trials matters because it ultimately affects health outcomes. In many instances, there is an overrepresentation of minority populations in Phase I, but they are vastly underrepresented ...
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(2015-08-03)Department: PhysicsStudies of the lambda and anti-lambda baryons in Au+Au collisions provide information on in-medium energy loss and hadronization mechanisms, which are important to understanding the quark-gluon plasma created in ...
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(Vanderbilt University, 2000)This paper argues that the interaction between inequality and the demand patterns for goods is a potential source of persistent inequality. Income distribution, in the presence of non-homothetic preferences, affect the ...
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(Wisconsin Law Review, 1992)The 1992 presidential election is over but the United States economy still faces hard times. Each man who hoped to lead us promised to revive our sick economy, and each cure promised included a strong dose of tax reform. ...