Browsing by Title
Now showing items 7361-7380 of 17439
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(2014-07-16)Department: PharmacologySynaptic transmission is characterized by exocytotic events which mediate the release of chemical transmitters to facilitate neuronal communication. Inhibitory presynaptic GPCRs act as feedback regulators limiting transmitter ...
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(2020-05-19)Department: NeuroscienceExcitatory signaling mediated by N-methyl-d-aspartate receptors (NMDARs) has been shown to regulate mood disorders. However, current treatments targeting NMDAR subtypes have shown limited success in treating patients, ...
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(2023-11-16)Department: Cell & Developmental BiologyActin-based protrusions are found on the surface of all eukaryotic cells, where they support diverse biological activities essential for life. Models of protrusion growth hypothesize that actin filament assembly provides ...
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(2017-05-26)Department: PharmacologyObsessive-compulsive disorder (OCD) is a chronic, disabling condition with inadequate treatment options that leave most patients with substantial residual symptoms. Structural, neurochemical, and behavioral findings point ...
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(2007-12-06)Department: Biological SciencesIn most eukaryotes, telomere length is maintained by telomerase, a ribonucleoprotein that adds TG-rich telomeric repeats de novo to chromosome ends. Telomeric binding proteins (for example, Rap1p) affect telomere length ...
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(2013-12-09)Department: Cell and Developmental BiologyDuring liver development, precise signaling is required to direct cell fate decisions and architectural establishment. It is hypothesized that the same signaling pathways are important in directing liver regeneration. To ...
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(Royal Society Open Science, 2019-10)The influential triple-code model of number representation proposed that there are three distinct brain regions for three different numerical representations: verbal words, visual digits and abstract magnitudes. It was ...
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(2009-01-15)Department: Biomedical EngineeringDiffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) technique that provides information about the organization and structural integrity of tissue. It has become an increasingly popular tool for investigation ...
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(2010-12-07)Department: Human GeneticsNeither genome size nor gene number is indicative of organism complexity. Complex regulation of genes within a genome likely contributes to organism complexity. Coordinate regulation of genes through shared cis regulatory ...
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(2007-04-04)Department: Molecular Physiology and BiophysicsTFIID is a multi-subunit protein complex that regulates activation of gene transcription. The coactivator model proposes that a given transcription factor activates transcription of its target gene by recruiting TFIID to ...
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(2014-11-26)Department: Biomedical EngineeringIn this study, parameters for the clinical application of optical neural stimulation were developed. Two pulsed diode lasers, with wavelengths centered at 1875 nm and 1450 nm respectively, were used to elicit compound motor ...
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(2022-05-12)Purpose: The long-term goal of this line of inquiry is to develop an ecologically valid and efficient measure of speech sound accuracy in connected speech that is suitable for use in clinical practice for children aged ...
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(Vanderbilt University. Peabody College, 2016-04)This project is a one‐year investigation of the nature of academic supports afforded to limited English proficient students in the Jefferson County Public Schools district in Louisville, KY. Surveys, interviews, observations, ...
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(2019-04-09)Department: Biomedical EngineeringPreterm birth (PTB) is the leading cause of death for children under 5, affecting 1 in 10 children in the United States. Premature infants are at a higher risk for infections and developmental issues. During pregnancy the ...
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(2011-12-08)Department: Molecular Physiology and BiophysicsPresently we do not completely understand how memories are able to store, retain, and recall information and experiences. The investigation is just beginning and proteins key for the biochemical processes associated with ...
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(2018-01-26)Department: Biomedical EngineeringMonitoring cervical composition during pregnancy has high potential for prediction of preterm birth, a problem affecting 15 million newborns annually. In vivo Raman spectroscopy (RS) is an optical technique that can measure ...
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(2017-08-28)Department: ChemistryIodolactonization is a venerable chemical reaction with considerable utility in the synthesis of organic compounds. More recently, enantioselective methods reliant upon organocatalysts have been developed. This work details ...
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(2022-02-15)Department: Electrical EngineeringOptical signal processing is a crucial field for meeting our growing information needs, finding use for example in fiber optics for long-haul telecommunications. There is currently an aim to bring optical technologies ...
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(2023-05-15)Department: Chemical EngineeringPorous silicon (PSi) has attracted interest as a nanomaterial with potential for optical biosensing, due to its high internal surface area, ease of fabrication, and versatile surface chemistry. Despite successful applications ...
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(2010-03-01)Department: Chemical EngineeringHeightened awareness in global warming and an increasing demand in energy consumption have generated a surging interest in creating sustainable alternative energy sources. One of the major challenges of incorporating ...