Browsing by Author "Aaron Bowman"
Now showing items 1-11 of 11
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Williams, Brooke Blairanne (2010-04-10)Department: NeuroscienceABSTRACT Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder predominantly afflicting the striatum. It is clear that an expansion of a glutamine encoding CAG triplet-repeat in the Huntingtin ...
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Ni, Mingwei (2011-11-23)Department: PharmacologyMercury accumulates in fish-eating populations. Glial cells have diverse functions including providing nutrition[1], maintaining CNS homeostasis, removing pathogens, inducing neuronal differentiation and mediating CNS ...
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Wenthur, Cody James (2015-07-15)Department: PharmacologyThe essential roles of glutamatergic signaling in both normal and impaired cognitive functioning have caused metabotropic glutamate (mGlu) receptors to become targets of interest for the treatment of psychiatric disorders. ...
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Kwakye, Gunnar Francis (2011-09-13)Department: NeuroscienceExpansion in the glutamine encoding CAG triplet-repeat in the Huntingtin (HTT) gene causes Huntington’s disease (HD). The susceptibility, age of onset, and severity of HD is modified by ill-defined genetic and/or environmental ...
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Bridges, Thomas Miller (2010-09-21)Department: PharmacologyThere exist five subtypes of the muscarinic acetylcholine receptor (M1-M5), which are differentially expressed throughout the body and play important roles in numerous physiological processes, including autonomic functions, ...
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Bryan, Miles Richard (2019-12-04)Department: NeuroscienceManganese is an essential micronutrient, required for the activity of many enzymes. Our lab has established that cellular and mouse models of Huntington’s Disease (HD) exhibit reduced striatal Mn bioavailability. This ...
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Gene-Environment Interactions Between Manganese Toxicity and Early-Onset Parkinson's Disease Genes Chakraborty, Sudipta (2015-03-26)Department: NeuroscienceParkinson’s disease (PD) is a neurodegenerative, motor disorder that is characterized by selective dopaminergic cell loss in the substantia nigra pars compacta. About 10-20% of PD cases have genetic causes; nonetheless, ...
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Mitchell, Amanda Christine (2011-12-09)Department: NeuroscienceMild, moderate, and vigorous physical activity are associated with decreased risks of Alzheimer’s disease, Parkinson’s disease, and a decreased infarct from stroke. Physical activity increases neurogenesis in the hippocampus ...
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Armstrong, Laura Craig (2017-09-21)Department: Cell and Developmental BiologyTuberous Sclerosis Complex (TSC) is a pediatric disorder of dysregulated growth and differentiation caused by loss of function mutations in either the TSC1 or TSC2 genes, which regulate mTOR kinase activity. TSC causes ...
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Balikov, Daniel Adam (2017-02-08)Department: Biomedical EngineeringRegenerative medicine has the potential to revolutionize how medical professionals approach combating and treating disease. Over the past several decades, human mesenchymal stem cells (hMSCs) have become one of the most ...
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Clay, Hayley Boyd (2016-06-03)Department: NeuroscienceDespite the presence of a cytosolic fatty acid synthesis pathway, mitochondria have retained their own means of creating fatty acids via the mitochondrial fatty acid synthesis (mtFASII) pathway. The reason for its conservation ...