Browsing by Author "Carlos Arteaga"
Now showing items 1-7 of 7
-
Nebhan, Caroline Amalia (2014-09-11)Department: Cancer BiologyLung cancer is the leading cause of cancer-related death in the United States and worldwide. Lung cancers that are driven by mutations in the Epidermal Growth Factor Receptor (EGFR) are treated with targeted anti-EGFR ...
-
Rosenbluth, Jennifer Margaret (2009-06-08)Department: Biochemistryp73, a transcription factor that plays essential roles during development and tumor suppression, shares significant sequence identity with p53. However, p53 and p73 are regulated by different pathways, and p73 is not ...
-
Davis, Michael Alan (2005-04-08)Department: Cancer Biologyp120 binds and is thought to regulate the cell-cell adhesion molecule E-cadherin. Experiments in a p120-deficient carcinoma cell line suggest a critical role for p120 in stabilizing E-cadherin. p120 downregulation occurs ...
-
Red Brewer, Monica (2009-09-04)Department: BiochemistryIn several growth factor receptors, the intracellular juxtamembrane (JM) region participates in autoinhibitory interactions that must be disrupted for tyrosine kinase activation. Using alanine scanning mutagenesis, I ...
-
Rioth, Matthew John (2016-04-11)Department: Biomedical InformaticsThesis under the direction of Dr. Jeremy L. Warner The practice of oncology increasingly relies on genetic information from tumors to determine diagnosis, prognosis and therapy. These tumor molecular profiling reports are ...
-
Myers, Matthew V (2012-01-25)Department: BiochemistryAnalysis of cellular signaling networks typically involves targeted measurements of phosphorylated protein intermediates. However, phosphoproteomic analyses usually require affinity enrichment of phosphopeptides and ...
-
Goodwin, Craig Matthew (2015-11-24)Department: PharmacologyMalignant cancers are the second leading cause of death in the United States, with a projected 1.6 million new diagnoses per year and almost 600,000 deaths. Our understanding of the molecular pathways causing tumor initiation, ...