Browsing by Author "Irina Kaverina"
Now showing items 1-19 of 19
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Sturgill, Emma Gray (2014-11-26)Department: Cell and Developmental BiologyMitotic kinesins represent the new age targets of spindle-poisoning chemotherapies. The kinesin-5 Eg5 is one such example, as kinesin-5 inhibitors (K5Is) induce a lethal mitotic arrest from failed spindle assembly. ...
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Landino, Jennifer Elaine (2017-03-30)Department: Cell and Developmental BiologyThe final steps of cell division are tightly coordinated in space and time but whether mechanisms exist to couple the actin and microtubule cytoskeletons during anaphase and cytokinesis (C phase) is largely unknown. We ...
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Levic, Daniel Scott (2015-11-27)Department: Cell and Developmental BiologyCargo trafficking is the process by which proteins and lipid carriers are transported between intracellular compartments. Mutations in components of cargo trafficking machinery have been associated with a diverse collection ...
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Branch, Kevin Michael (2012-08-31)Department: Cancer BiologyThese studies tested the hypothesis that cell-extracellular matrix (ECM) interactions promote the maturation of invadopodia to fully functional structures. I demonstrate that invadopodia-associated ECM degradation is ...
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Fenix, Aidan Mandy (2018-11-19)Department: Cell and Developmental BiologyForce generation at the cellular level is critical for eukaryotic development, homeostasis, and the progression of force dependent diseases such as cancer. Molecular motors coordinate with cytoskeletal elements, such as ...
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Shannon, Erica Kristine (2017-09-14)Department: Cell and Developmental BiologyIn normal epithelial wound repair, cells across an epithelial sheet begin a coordinated process of re-epithelialization within minutes of wounding. These coordinated behaviors are driven by a calcium wave, a rise in ...
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Folkmann, Andrew William (2014-05-27)Department: Cell and Developmental BiologyA critical step during gene expression is the directional export of nuclear messenger (m)RNA through nuclear pore complexes (NPCs) to the cytoplasm. During export, Gle1 in conjunction with inositol hexakisphosphate (IP6) ...
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Miller, Paul Myron (2010-08-02)Department: Cell and Developmental BiologyThis project provides a detailed characterization of the CLASP-dependent microtubule array at the Golgi in terms of function and regulation. First, I briefly outline the process of MT nucleation at the Golgi and highlight ...
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Postema, Meagan Marie (2019-09-17)Department: Cell and Developmental BiologyThe intestinal brush border lines the apical surface of enterocytes and is composed of thousands of actin-supported protrusions called microvilli, which extend into the intestinal lumen. Microvilli function to increase ...
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Willet, Alaina Hollister (2017-08-11)Department: Cell and Developmental BiologyIn Schizosaccharomyces pombe cytokinesis requires assembly and constriction of an actomyosin-based contractile ring (CR). Nucleation of F-actin for the CR requires a single essential formin, Cdc12, that localizes to the ...
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Knowlton, Jonathan James (2018-07-12)Department: Microbiology and ImmunologyProtein folding encompasses the biological process by which a polypeptide achieves its functional three-dimensional conformation. Although some proteins can spontaneously reach their native shape, others cannot fold without ...
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Moynihan, Katherine Lynn (2009-12-07)Department: Cell and Development BiologyThis project characterizes CENP-F protein function at a cellular and organ level. First, I outline our plan used to identify novel binding partners. The first binding partner I describe is syntaxin 4 and the interaction ...
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Benesh, Andrew Eugene (2011-12-12)Department: Cell and Developmental BiologyClass I myosins are monomeric actin-binding, ATP hydrolyzing molecular motors that are expressed in a variety of cell types, and function at the membrane-actin interface. Myosin-1d, one of eight vertebrate class I myosins, ...
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Gayek, Anna Sophia (2016-03-30)Department: Cell and Developmental BiologyTwo processes influence the success of mitosis, the process by which eukaryotic cells divide their replicated genome into two new daughter cells. First, the cell must build a bipolar array of microtubules called the mitotic ...
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Harris, Jana Eleonore (2006-11-01)Department: Cell and Developmental BiologyThe microtubule cytoskeleton of most animal oocytes differs from that of somatic cells in that the centrioles are lost during oogenesis. In most animals, female meiotic spindles assemble in the absence of centrosomes; ...
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Dumas, Megan Elissa (2019-05-15)Department: Cell and Developmental BiologyThe mitotic spindle is the microtubule (MT)-based machine that segregates a replicated set of chromosomes during cell division. Many chemotherapeutics target the mitotic spindle by altering or disrupting microtubules, the ...
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Jodoin, Jeanne Nicole (2013-12-10)Department: Cell and Developmental BiologyCytoplasmic dynein is a large, multimeric complex that walks along microtubules to perform multiple functions within the cell. This motor is commonly found associated with the dynein-activating complex, dynactin. Dynein ...
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Broussard, Joshua Allen (2012-06-19)Department: Biological SciencesCell migration is a complex process that requires the coordination of signaling events that take place in distinct locations within the cell. Adaptor proteins are emerging as key modulators of spatially integrated processes ...
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Meenderink, Leslie M. (2010-10-22)Department: Cell and Developmental BiologyThe docking protein p130Cas is a prominent Src substrate found in focal adhesions (FAs) and is implicated in regulating critical aspects of cell motility including FA disassembly and protrusion of the leading edge plasma ...