Browsing by Author "Sachin Patel"
Now showing items 1-10 of 10
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Fetterly, Tracy Lynne (2018-09-18)Department: NeuroscienceStress contributes to numerous psychiatric disorders. CRF signaling in the bed nucleus of the stria terminalis (BNST) drives negative affective behaviors, thus agents that decrease activity of these cells may be of therapeutic ...
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Hartley, Nolan D. (2019-09-13)Department: NeuroscienceAcquisition and extinction of learned fear responses utilize flexible yet conserved neural circuits that promote or suppress fear expression, respectively. Here we show that acquisition of passive fear behavior is associated ...
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Gamble-George, Joyonna Carrie (2016-08-01)Department: NeuroscienceCannabinoid receptors have been examined as potential targets to alleviate the negative consequences of anxiety, trauma-related, and stress-related disorders. However, in preclinical animal studies, synthetic cannabinoids ...
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Manz, Kevin Michael (2019-12-05)Department: NeuroscienceThe nucleus accumbens (NAc) is implicated in the pathogenesis of conditions characterized by maladaptive motivational states, including addiction and depression. Embedded within the mesolimbic network, the NAc coordinates ...
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Moran, Sean p (2019-12-03)Department: NeuroscienceMuscarinic acetylcholine receptors (mAChR) play important roles in regulating complex behaviors such as cognition, movement, and reward, making them ideally situated as potential drug targets for the treatment of several ...
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Turner, Brandon David (2018-08-06)Department: NeuroscienceThe nucleus accumbens has been repeatedly identified as a central node in reward processing. Plasticity of synaptic connections within the accumbens at the molecular and cellular level is well understood to serve a pivotal ...
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Holleran, Katherine Mercedes (2016-02-09)Department: NeuroscienceMajor depressive disorder (MDD) represents an enormous societal burden that will directly affect nearly one fifth of Americans within their lifetime. Despite its high prevalence and contribution to disability, current ...
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Hermanson, Daniel John (2014-04-08)Department: ChemistrySubstrate-selective Inhibition of Cyclooxygenase-2: Molecular Determinants, Probe Development, and In Vivo Effects. Daniel John Hermanson Dissertation under the direction of Professor Lawrence J. Marnett Cyclooxygenase-2 ...
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Flavin, Stephanie Anne (2014-09-10)Department: NeuroscienceDrug addiction is a chronically relapsing disorder characterized by cycles of drug use, withdrawal, and relapse. Stress-induced relapse of drug use is a significant barrier to curing addiction. The bed nucleus of the stria ...
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Bluett, Rebecca J. (2017-04-10)Department: NeuroscienceNearly 30% of the global burden of nonfatal disease is due to affective disorders. Stress is a potent risk factor for affective disorders including major depression and posttraumatic stress disorder. The neurobiological ...