Browsing by Department "Microbe-Host Interactions"
Now showing items 1-20 of 45
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(2020-04-03)Department: Microbe-Host InteractionsMosquito inoculation of humans with arthritogenic alphaviruses results in a febrile syndrome characterized by debilitating musculoskeletal pain and arthritis. Despite an expanding global disease burden, no approved therapies ...
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(2021-05-17)Department: Microbe-Host InteractionsInfection remains a common and deadly risk for vulnerable patients due to rising antibiotic resistance, aging populations, and increasingly complex medical care. Prophylactic immunomodulation that bolsters host immunity ...
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Characterization of functional human antibodies targeting henipavirus and flavivirus glycoproteins (2021-06-14)Department: Microbe-Host InteractionsThe henipaviruses Hendra (HeV) and Nipah (NiV), and the flavivirus yellow fever (YFV), pose massive global public health threats. No small molecule or antibody-based countermeasures are available to treat humans infected ...
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(2024-03-20)Department: Microbe-Host InteractionsThis thesis explores the intricate mechanisms by which the human immune system generates antibodies to fend off diseases, focusing on the response to Influenza Type B virus. The ability of the immune system to produce ...
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(2022-07-20)Department: Microbe-Host InteractionsHantaviruses are high-priority emerging pathogens carried by rodents and transmitted to humans by aerosolized excreta or, in rare cases, person-to-person contact. While sporadic in North and South America, many infections ...
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(2022-11-18)Department: Microbe-Host InteractionsViruses with multi-segmented genomes are unique in their capacity to readily exchange large amounts of genetic information via a process known as reassortment. Reassortment requires a considerable amount of genetic ...
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(2022-01-04)Department: Microbe-Host InteractionsCoronaviruses (CoVs) are a genetically diverse group of positive-sense single-stranded RNA viruses containing the largest known genome of any RNA virus, >30 kb, and responsible for the current COVID-19 pandemic (SARS-CoV-2). ...
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(2022-03-15)Department: Microbe-Host InteractionsUropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections and among the most successful human bacterial pathogens worldwide. Despite being a facultative anaerobe, UPEC requires aerobic respiration ...
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(2022-06-10)Department: Microbe-Host InteractionsGroup B Streptococcus (GBS), or Streptococcus agalactiae, is one of the leading causes of infection-related adverse pregnancy and neonatal outcomes, which include stillbirth, chorioamnionitis, preterm birth, and neonatal ...
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(2024-03-21)Department: Microbe-Host InteractionsUropathogenic Escherichia coli (UPEC) is one of the most prevalent human pathogens, causing about 80% of urinary tract infections (UTI) in the world. To establish an infection in the bladder, UPEC must survive in the ...
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(2024-03-21)Department: Microbe-Host InteractionsUropathogenic Escherichia coli (UPEC) is one of the most prevalent human pathogens, causing about 80% of urinary tract infections (UTI) in the world. To establish an infection in the bladder, UPEC must survive in the ...
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(2024-03-21)Department: Microbe-Host InteractionsUropathogenic Escherichia coli (UPEC) is one of the most prevalent human pathogens, causing about 80% of urinary tract infections (UTI) in the world. To establish an infection in the bladder, UPEC must survive in the ...
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(2022-03-24)Department: Microbe-Host InteractionsExisting viral pathogens like human immunodeficiency virus (HIV), influenza virus, and coronaviruses, along with emerging infectious diseases, are constant worldwide threats, causing illness and death for millions of people ...
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(2024-03-21)Department: Microbe-Host InteractionsHuman immunodeficiency virus (HIV) is a significant public health threat and the causative agent of acquired immunodeficiency syndrome (AIDS). Studying the antibody response in the context of HIV-1 infection and multivalent ...
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(2023-03-27)Department: Microbe-Host InteractionsDuring a field expedition with the Centers for Disease Control and Prevention to South Sudan and Uganda, a wildlife researcher who had been collecting bat and rodent samples became ill and was hospitalized with a severe ...
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(2024-03-20)Department: Microbe-Host InteractionsCoronaviruses (CoVs) are single-stranded, positive-sense RNA viruses that infect a wide variety of species including birds, reptiles, and mammals. SARS-CoV-2 is only the latest coronavirus to jump from animals into humans ...
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(2022-05-16)Department: Microbe-Host InteractionsAntibiotic resistance is a growing global health threat. According to the CDC, nearly 2.8 million drug-resistant infections occur every year, killing 35,000 people annually. While research has focused on the acquisition ...
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(2020-02-03)Department: Microbe-Host InteractionsFunctional coupling between the amygdala and the dorsomedial prefrontal cortex (dmPRC) has been implicated in the generation of negative affective states under stressful conditions in both humans and rodents; however, the ...
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(2022-06-14)Department: Microbe-Host InteractionsGram-negative bacteria are frequently opportunistic pathogens that cause significant morbidity and mortality in humans. Escherichia coli and Klebsiella pneumoniae are two common Gram-negative pathogens that often acquire ...
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(2024-02-27)Department: Microbe-Host InteractionsColonization of the human stomach by Helicobacter pylori is the primary risk factor for development of gastric cancer. H. pylori infection stimulates a gastric mucosal inflammatory response and can trigger a cascade of ...