Browsing by Subject "Anaphase Promoting Complex"
Now showing items 1-3 of 3
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(2010-08-05)Department: Cell and Developmental BiologyMutations in human microcephalin (MCPH1) result in a form of autosomal recessive primary microcephaly, a disorder of fetal brain growth characterized by a severely reduced cerebral cortex and head size with mental retardation. ...
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(2013-04-15)Department: Biological SciencesThe work presented in this dissertation focuses on the temporal regulation of telomerase complex assembly in the yeast Saccharomyces cerevisiae as mediated by protein degradation of a core subunit during G1 phase of the ...
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(2014-08-18)Department: Cell and Developmental BiologyIn a biochemical screen Anaphase-Promoting Complex (APC) substrates, we identified Drosophila MCPH1 isoform B (dMCPH1-B) as a substrate of APCCdh1. dMCPH1-B undergoes Cdh1-dependent degradation in Xenopus egg extract, which ...