Browsing by Subject "BNST"
Now showing items 1-8 of 8
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An ensemble recruited by α2a-adrenergic receptors is engaged in a stressor-specific manner in mice (2022-11-14)Department: Pharmacologyα2a-adrenergic receptor (α2a-AR) agonists are candidate substance use disorder therapeutics due to their ability to recruit noradrenergic autoreceptors to dampen stress system engagement. However, we recently found that ...
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(Neuroimage, 2020-04-15)The bed nucleus of the stria terminalis (BNST) is emerging as a critical region in multiple psychiatric disorders including anxiety, PTSD, and alcohol and substance use disorders. In conjunction with growing knowledge of ...
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(2021-05-11)Department: NeuroscienceAlcohol use disorder (AUD) affects over 15 million Americans and remains exceptionally difficult to treat, with the majority of individuals relapsing within a year of initiating treatment. Much of this difficulty is thought ...
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(2021-05-11)Department: NeuroscienceStress is critical to every organism’s ability to adapt and survive. This dissertation reviews the history of stress research and reviews stress physiology across a variety of organ systems. Neurocircuitry that is involved ...
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(2020-05-19)Department: NeuroscienceExcitatory signaling mediated by N-methyl-d-aspartate receptors (NMDARs) has been shown to regulate mood disorders. However, current treatments targeting NMDAR subtypes have shown limited success in treating patients, ...
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(2016-02-09)Department: NeuroscienceMajor depressive disorder (MDD) represents an enormous societal burden that will directly affect nearly one fifth of Americans within their lifetime. Despite its high prevalence and contribution to disability, current ...
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(2014-09-10)Department: NeuroscienceDrug addiction is a chronically relapsing disorder characterized by cycles of drug use, withdrawal, and relapse. Stress-induced relapse of drug use is a significant barrier to curing addiction. The bed nucleus of the stria ...
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(2023-03-27)Department: NeuroscienceThe bed nucleus of the stria terminalis (BNST) is a critical mediator of stress responses and anxiety-like behaviors. Neurons expressing protein kinase C delta (BNST(PKCδ)) are an abundant but understudied subpopulation ...