Browsing by Subject "ETAA1"

Now showing items 1-2 of 2

    • A common mechanism of ATR activation by TOPBP1 and ETAA1 
      Thada, Vaughn; 0000-0002-9245-4354 (2021-02-12)
      Department: Biochemistry
      Human cells are constantly exposed to endogenous and exogenous sources of DNA damage that cause thousands of DNA lesions in each cell every day. Accurate repair of these lesions ensures maintenance of genome stability and ...
    • ETAA1 promotes genome stability through activation of ATR 
      Bass, Thomas Edwin (2018-11-21)
      Department: Biochemistry
      The ATR kinase controls cell cycle transitions and the DNA damage response. Budding yeast contain three activators of Mec1ATR; however, only TOPBP1 is known to activate ATR in vertebrates. We identified ETAA1 as a replication ...