Browsing by Subject "GABA"
Now showing items 1-13 of 13
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(2012-12-07)Department: NeuroscienceThe proper function of the nervous system is dependent upon a delicate balance between excitatory and inhibitory activity in the brain. GABAA receptors are extremely important in the maintenance of this balance because ...
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(2014-04-09)Department: NeuroscienceGABA-ergic disturbances are hallmark features of many brain disorders. Two transgenic mouse lines were generated to suppress GAD1 in non-overlapping cell types that express cholecystokinin (CCK) or neuropeptide Y (NPY). ...
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(2013-07-18)Department: NeuroscienceGABAA receptors are pentameric, ligand-gated chloride channels that mediate the majority of fast inhibition in the brain. Because they are assembled from an array of 19 subunit subtypes, GABAA receptors are remarkable ...
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(2013-07-29)Department: Biological SciencesThe social amoeba Dictyostelium discoideum senses the bacterial metabolite folic acid to track down bacteria. Previous studies suggested that the folic acid receptor is a serpentine receptor. In this study, I examined the ...
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(2010-04-10)Department: PharmacologyGABA functions as the primary inhibitory neurotransmitter in the mammalian brain. In hippocampus, GABA serves multiple roles during development and throughout adulthood, which include: 1) orchestrate synapse maturation ...
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(2005-03-09)Department: Molecular Physiology and BiophysicsAutism is a severe neurodevelopmental disorder characterized by deficits in language and social interaction, and patterns of repetitive and stereotyped behaviors, interests and activities. Evidence indicates that autism ...
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(2016-07-27)Department: Biological SciencesRetina damage or disease in humans often leads to reactive gliosis, preventing the formation of new cells and resulting in visual impairment or blindness. Currently, treatments are being developed to stimulate repair or ...
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(2013-07-11)Department: Cell and Developmental BiologyNeurodegenerative diseases are characterized by inappropriate death of distinct neuronal populations. Although symptoms vary, these diseases share pathogenic features such as age-dependent onset and progressive death of ...
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(2007-08-01)Department: NeuroscienceDuring postnatal development of the central nervous system, the response of GABAA receptor to its agonist undergoes a switch from excitatory to inhibitory, due to a developmental decrease in the intracellular Cl- concentration. ...
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(2010-04-16)Department: NeuroscienceGABA-A receptors are ligand-gated chloride channels that mediate the majority of fast inhibitory signaling in the central nervous system. Their kinetic properties determine the charge transfer and timing of inhibitory ...
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(2013-04-09)Department: PhysicsMagnetic Resonance Spectroscopy (MRS) is a powerful technique that can potentially be used to measure metabolite concentrations in the brain non-invasively. However, the available signal-to-noise ratios (SNR) of MR spectra ...
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(2007-12-13)Department: Cell and Developmental BiologyDissertation under the direction of Professor David M. Miller III Impairment of neurons expressing the neurotransmitter ?-amminobutyric acid (GABA) can result in psychiatric diseases as diverse as schizophrenia, epilepsy, ...
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(2014-02-11)Department: NeuroscienceEpilepsy is a disease characterized by two or more unprovoked seizures. Two mutations, S326fs328X and A322D, in the α1 subunit of GABAA receptor (Gabra1), are associated with childhood absence epilepsy and juvenile myoclonic ...