Browsing by Subject "Macrophages"

Now showing items 1-3 of 3

    • Leptin Repolarizes Tumor-Associated Macrophages to Boost Immunotherapy Efficacy in Obesity 
      Dudzinski, Stephanie Odette; 0000-0001-9222-472X (2020-08-06)
      Department: Biomedical Engineering
      Immunotherapy is life-saving for some cancer patients and while obesity can promote cancer, it may also increase immunotherapy efficacy. Mechanisms of this effect have been unclear, although obesity can promote an ...
    • Leveraging Tumor-Associated Macrophages for Anti-Cancer Immunotherapy Using Injectable Biomaterials 
      Glass, Evan Bryce; 0000-0002-3169-1866 (2022-01-06)
      Department: Biomedical Engineering
      Macrophages are the most abundant immune cell in most tumors and are drivers of the immunosuppressive tumor microenvironment. Macrophages exist across a range of phenotypes with the two extremes often termed “M1” for ...
    • Myeloid Cell-Derived HB-EGF Drives Tissue Recovery After Pancreatitis 
      Wen, Hui-Ju; Gao, Shan; Wang, Yin; Ray, Michael; Magnuson, Mark A.; Wright, Christopher V. E.; Di Magliano, Marina Pasca; Frankel, Timothy L.; Crawford, Howard C. (Cellular and Molecular Gastroenterology and Hepatology, 2019)
      BACKGROUND & AIMS: Pancreatitis is a major cause of morbidity and mortality and is a risk factor for pancreatic tumorigenesis. Upon tissue damage, an inflammatory response, made up largely of macrophages, provides multiple ...