Browsing by Subject "TGF-beta"
Now showing items 1-8 of 8
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(Vanderbilt University. Medical Center, 2007-07-06)
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(2010-09-22)Department: Cancer BiologyProgression to castrate resistant prostate cancer (CRPC) is associated with high morbidity. Disease recurrence and progression is influenced by the tumor microenvironment. Resident and recruited stroma contribute to cancer ...
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(2012-07-26)Department: Cancer BiologyTransforming growth factor-beta (TGF-β) has a dual role during tumor progression initially as a suppressor and then as a promoter. Much is known about the contribution of TGF-β signaling to tumorigenesis, yet, the role ...
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(2013-07-29)Department: Cell and Developmental BiologyMy study of three signaling pathways in the context of three gastrointestinal diseases is presented here. Firstly, the epidermal growth factor receptor (EGFR) pathway and its role in the pathogenesis of the hypertrophic ...
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(2006-07-07)Department: Cancer BiologyContribution of stromal TGF-b to prostate cancer progression Human prostate carcinoma-associated fibroblasts (CAF) induce malignant transformation in an initiated but non-malignant human prostatic epithelial cell line ...
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(2011-12-15)Department: PharmacologyCoronary artery disease accounts for 54% of all cardiovascular disease in the United States. To provide novel therapeutic targets for the prevention and treatment of coronary artery disease, my dissertation project focused ...
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(2006-04-14)Department: Cell and Developmental BiologyWhile localized tumor growth may cause organ dysfunction and even death, metastases cause the vast majority (~90%) of human cancer deaths. Both autocrine and paracrine transforming growth factor-beta (TGF-beta) have been ...
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(2008-04-14)Department: Cancer BiologyColon cancers arise as the consequence of the accumulation of mutations and epigenetic alterations in normal cells that lead to the transformation of these cells into cancer. One way through which these genetic and ...