Browsing by Subject "bone"
Now showing items 1-11 of 11
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(2016-06-01)Department: Biomedical EngineeringThe current standard for diagnosing fracture risk comprises measurements of bone mineral density (BMD), primarily by dual-energy X-ray absorptiometry (DXA). However, bone strength is affected by many factors other than ...
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(2018-07-30)Department: Biomedical EngineeringFracture resistance of bone depends on the hierarchical organization of its constituents, primarily the organic matrix, mineral, and water, and as such, requires characterization at multiple length-scales. The extracellular ...
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(2010-12-16)Department: Chemical EngineeringHealing of bone defects such as open fractures is a challenging clinical problem. An ideal treatment for bone defects would restore both form and function of the tissue. In this research, a two-component allograft bone ...
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(2010-12-13)Department: Molecular Physiology and BiophysicsAll eukaryotic and some prokaryotic ClC anion transport proteins have extensive cytoplasmic C-termini containing two cystathionine-beta-synthase (CBS) domains. CBS domain secondary structure is highly conserved and consists ...
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(2019-09-17)Department: PharmacologyThe sympathetic nervous system is a major efferent pathway through which the central nervous system controls peripheral organ function. Genetic and pharmacologic evidence in mice indicated that stimulation of the β2 ...
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(2009-07-07)Department: Cancer BiologyBreast to bone metastasis is a common event during breast cancer progression. The resultant lesions often cause extensive bone destruction that results in a number of complications including intense pain that dramatically ...
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(2013-12-04)Department: Chemical EngineeringThere is a compelling clinical need for grafts with initial bone-like mechanical properties that remodel and promote healing of bone defects. This dissertation describes the development and characterization of biodegradable ...
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(2019-03-29)Department: Cancer BiologyDespite the high prevalence of breast cancer metastasis to bone, there are currently no therapeutic options to cure metastatic disease. This deficit is in part due to the lack in vivo models that recapitulate prolonged ...
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(2011-08-30)Department: Cancer BiologyBreast cancer frequently metastasizes to the skeleton with severe consequence to patient quality of life. Patients who develop bone metastases suffer from severe bone pain and increased risk of developing hypercalcemia ...
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(Frontiers In Ecology And Evolution, 2022-12-20)Studies of Rancho La Brea predators have yielded disparate dietary interpretations when analyzing bone collagen vs. enamel carbonate-requiring a better understanding of the relationship between stable carbon isotopes in ...
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Signaling Mechanisms Controlling Bony Invasion and Bone Destruction in Oral Squamous Cell Carcinoma (2016-11-30)Department: Cancer BiologyOral Squamous Cell Carcinoma (OSCC) is the sixth most common cancer worldwide. OSCC commonly invades into the lymph nodes and mandible, which correlate with increased rates of recurrence and lower overall survival. Tumors ...