Browsing by Subject "cadherin"
Now showing items 1-5 of 5
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(2005-04-08)Department: Cancer Biologyp120 binds and is thought to regulate the cell-cell adhesion molecule E-cadherin. Experiments in a p120-deficient carcinoma cell line suggest a critical role for p120 in stabilizing E-cadherin. p120 downregulation occurs ...
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(2007-04-06)Department: Cancer BiologyIntegration of receptor tyrosine kinase, integrin, and cadherin activities is crucial for normal cell growth, motility and adhesion. Here, we describe novel roles for p120 catenin (p120) and p190RhoGAP that coordinate ...
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(2015-12-09)Department: Cancer BiologyIn vertebrate epithelia, p120-catenin mediates E-cadherin stability and suppression of RhoA. Genetic ablation of p120 in various epithelial tissues typically causes striking alterations in tissue function and morphology. ...
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(2011-04-02)Department: Cancer Biologyp120 catenin (p120) binds and stabilizes classical cadherins, making it a critical regulator of cell-cell adhesion. Here, we report an efficient technique (designated ReCLIP for Reversible Cross-Link Immuno-Precipitation) ...
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(2012-04-04)Department: Cancer BiologyCadherins and catenins are important regulators of tissue homeostasis and cancer. Here, we report critical roles for p120 catenin (p120) in mammary development and breast cancer. In the untransformed gland, p120 ablation ...