Browsing by Subject "cancer therapy"

Now showing items 1-2 of 2

    • Pharmacological WDR5 WIN site inhibition as an anti-leukemia target 
      Aho, Erin Renee (2019-05-16)
      Department: Cell and Developmental Biology
      The epigenetic regulator WDR5 is a promising therapeutic target in leukemias expressing oncogenic translocations of the MLL1 histone methyltransferase gene. Despite the validation of the WIN site of WDR5 as a pharmacological ...
    • The WDR5 interaction network 
      Guarnaccia, Alissa duPuy; 0000-0003-4195-2158 (2021-02-10)
      Department: Cell & Developmental Biology
      WDR5 is a conserved WD40-repeat protein that rose to prominence through its role in epigenetic complexes, including the KMT2 (MLL/SET) enzymes that deposit histone H3 lysine 4 methylation and the non-specific lethal complex ...