Browsing by Subject "p53 family"
Now showing items 1-3 of 3
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(2016-03-18)Department: BiochemistryThe pivotal role of the transcription factor p53 in tumor suppression remains unchallenged; however, the role of its family member, p73, in normal cellular function and tumorigenesis is far from certain. The goal of this ...
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(2019-11-01)Department: Biochemistryp63 is a transcriptional regulator of ectodermal development that is required for basal cell proliferation and stem cell maintenance. p73 is a closely related p53 family member that is expressed in select p63-positive basal ...
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(2018-10-30)Department: BiochemistryThe p53 family of transcription factors, p53, p63 and p73, regulate a wide array of cellular processes from cell cycle control to organ development and cell differentiation. The goal of this dissertation is to understand ...