Browsing by Subject "schizophrenia"
Now showing items 1-20 of 29
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(2003-12-17)Department: PsychologyCognitive impairment represents a core feature of schizophrenia and a major impediment to social and vocational rehabilitation. First generation antipsychotic (FGA) medications do not elicit robust cognitive changes, but ...
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(2005-08-12)Department: PsychologyWorking memory deficit has been suggested to be a cardinal feature of schizophrenia, but the causes of this deficit have not been determined. This dissertation intended to augment our understanding of the etiology of working ...
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(2019-05-07)Department: PsychologyIndividuals with schizophrenia (ISZ) are among the most socially isolated and stigmatized individuals in our society. Mounting evidence suggests powerful detrimental effects of loneliness as a result of dissonance between ...
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(2017-09-18)Department: PsychologyAnomalous or weakened sense of self was central to early theories of schizophrenia. Recent empirical studies have also documented disturbances in body ownership and increased susceptibility for dissociative experiences ...
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(2015-11-19)Department: NeuroscienceDue to the escalating obesity epidemic in the United States, an important public health concern is the comorbidity of metabolic disorders and mental illness. Mounting clinical evidence supports the comorbid nature of mental ...
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(2014-04-09)Department: NeuroscienceGABA-ergic disturbances are hallmark features of many brain disorders. Two transgenic mouse lines were generated to suppress GAD1 in non-overlapping cell types that express cholecystokinin (CCK) or neuropeptide Y (NPY). ...
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(2011-12-04)Department: NeuroscienceEmbryonic dopamine (DA) receptor (DR) expression in the medial frontal cortex (mFC) coincides with the formation of neural circuits during the period of axon pathfinding but the signaling properties of DRs and their effect ...
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(2015-08-03)Department: PsychologyIndividuals with schizophrenia (SZ) have been shown to exhibit deficits in detecting human agents against background noise, such that the signal-to-noise ratio of biological motion perception is significantly reduced. Such ...
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(Vanderbilt University, 2014-04-15)A reliable and valid neurophysiological index of error-monitoring ability is an eventrelated potential (ERP) known as “error-related negativity” (ERN), which is evoked following an error response. Individuals with schizophrenia ...
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(2022-07-18)Department: PsychologyEmbodiment deficits were central to early theories of schizophrenia and remain at the phenomenological core of the disorder. Contemporary evidence confirms disturbances of the bodily self as central to schizophrenia and ...
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(2016-11-21)Department: PharmacologyCurrent antipsychotic medications (APDs) for schizophrenia primarily treat positive symptoms (hallucinations, delusions) yet are largely ineffective in treating the negative (anhedonia, social withdrawal, apathy) and ...
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High angular resolution diffusion imaging of brain white matter and its application to schizophrenia (2010-04-10)Department: Biomedical EngineeringBy sampling the self-diffusion of water molecules, diffusion tensor imaging (DTI) is able to characterize the microstructure of brain white matter. Previous DTI studies in schizophrenia have reported white matter alterations ...
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(2016-04-08)Department: PsychologySince the time of Kraepelin (1896) and Bleuler (1911) nearly every description of schizophrenia cognitive dysfunction highlights impairments in attention, yet the locus of this deficit is not well understood. One model ...
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(2011-08-01)Department: PsychologyIndividuals with schizophrenia (SZ) consistently show impairment of facial emotion recognition, but underlying mechanisms that give rise to this difficulty have not been elucidated. Given the findings of abnormalities in ...
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(2012-07-19)Department: PsychologyCognitive dysfunction is a core feature of schizophrenia, but the precise nature of these deficits has yet to be delineated. The goal of the following series of experiments was to advance our understanding of two particular ...
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(2010-04-15)Department: PharmacologyMuscarinic acetylcholine receptors (mAChRs), specifically M1 and M4 subtypes, provide viable targets for the treatment of multiple central nervous system disorders. However, highly selective activators of either M1 or M4 ...
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(2019-03-19)Department: NeuroscienceExcessive synaptic elimination during adolescence has been suggested to reduce the density of dendritic spines on pyramidal cells (PCs) in the prefrontal cortex (PFC), thereby contributing to the cognitive deficits of ...
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(2013-04-15)Department: PharmacologyMetabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that play important roles in the modulation of neurotransmission in the central nervous system (CNS). The eight subtypes of mGluRs are differentially ...
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(2022-03-27)Department: NeuroscienceParvalbumin interneurons (PV-INs), a subset of inhibitory interneurons, are defined by their fast-spiking phenotype and by the presence of the calcium-binding protein parvalbumin. PV-INs are vulnerable to many stressors, ...
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(Vanderbilt University, 2011-04-22)Using prosodic, facial, and musical stimuli, this study probed the extent of emotion recognition deficits in schizophrenic patients. Difficulties in the perception of emotional material have been well documented in the ...