Browsing by Subject "zebrafish"
Now showing items 1-20 of 20
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(2013-06-17)Department: Human GeneticsA BIPHASIC ROLE FOR THE VOLTAGE-GATED SODIUM CHANNEL SCN5LAB IN CARDIAC DEVELOPMENT OF ZEBRAFISH JEFFREY S. BENNETT Dissertation under direction of Professor Dan M. Roden, M.D. Voltage-gated sodium channels (VGSCs) play ...
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(2014-09-25)Department: Biological SciencesThe zebrafish epithalamus, which includes the dorsal habenular nuclei and pineal complex, displays robust molecular and anatomical asymmetries. The full elaboration of molecular and anatomical differences between the left ...
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(2022-03-23)Department: NeuroscienceThe vertebrate head is a complex structure consisting of diverse tissues that work cooperatively to perform a variety of craniofacial functions, such as speaking, breathing, processing and swallowing food, among others. ...
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(2009-07-19)Department: Biological SciencesDuring spinal cord development, precursor cells transition from proliferative divisions to differentiative divisions. Traditionally proliferative divisions, which increase cell numbers, are thought to be symmetric, whereas ...
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(2008-03-13)Department: Biological SciencesDopamine plays key roles in many basic functions in the central nervous system. In order to study developmental and functional roles of dopaminergic cells in the zebrafish, we have examined a transgenic line of zebrafish ...
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(2006-04-28)Department: Cell and Developmental BiologyProstaglandin G/H synthases (PGHS), commonly referred to as cyclooxygenases (COX-1 and COX-2), catalyze a key step in the synthesis of biologically active prostaglandins (PGs), the conversion of arachidonic acid (AA) into ...
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(2007-12-04)Department: Biological SciencesIn recent years it has become apparent that microRNAs (miRNAs) are common feature of eukaryotic genomes. The functional products of these non-canonical genes are small, ~22nt RNAs that negatively regulate translation. ...
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(2011-12-12)Department: NeuroscienceSonic hedgehog (Shh) signaling regulates cell growth during embryonic development, tissue homeostasis and tumorigenesis. Concentration-dependent cellular responses to secreted Shh protein are essential for tissue patterning. ...
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(2011-06-28)Department: Biological SciencesBIOLOGICAL SCIENCES KCTD12 PROTEINS REGULATE ULK2 TO CONTROL THE DEVELOPMENT OF ASYMMETRIC HABENULAR NEUROPIL ROBERT W. TAYLOR Dissertation under the direction of Professor Joshua T. Gamse The habenular nuclei (Hb) are ...
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(2018-10-23)Department: Biological SciencesmicroRNAs (miRNAs) are a family of highly conserved small noncoding RNAs that post transcriptionally regulate gene expression and play important roles in many cellular processes during development and regeneration. The ...
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(2015-02-03)Department: Biological SciencesmicroRNAs (miRNAs) are small noncoding RNAs that bind the 3’ untranslated regions (UTRs) of mRNA targets and, acting with associated proteins, facilitate translation repression and degradation of target mRNAs. Since their ...
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(2010-07-09)Department: Biological SciencesmicroRNAs (miRNAs) are short non-coding RNAs that down-regulate gene expression by pairing with sequences in the 3’UTR of target mRNAs. They play critical roles in diverse developmental and physiological events but the ...
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(2014-07-16)Department: Biological SciencesZebrafish spontaneously regenerate their retinas after a variety of retinal insults. Key to regeneration are resident support cells called Müller glia (MG), which respond to injury by reverting to a stem cell-like state ...
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(2018-07-16)Department: Chemical and Physical BiologyαB-crystallin is a member of the small heat shock protein (sHSP) superfamily. Mutations in αB-crystallin cause autosomal cataracts and cardiomyopathy, but the exact role of αB-crystallin in the lens and heart remains ...
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(2009-04-01)Department: NeuroscienceIn the spinal cord, most oligodendrocytes, the myelinating cell type of the CNS, and motor neurons arise from common, ventral, olig2-expressing precursors called pMN cells. In the hindbrain, the degree to which motor neurons ...
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(2013-07-02)Department: Biological SciencesmicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level by specific binding to recognition elements in the 3’ untranslated regions (UTRs) of target mRNAs. In zebrafish ...
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(2014-07-28)Department: Biological SciencesSmall noncoding RNAs including miRNAs and siRNAs play significant roles in gene regulation via the mechanism of RNA interference (RNAi) and have been exploited to conduct loss-of-function studies. The discovery that these ...
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(2008-12-06)Department: PharmacologyElectrical signaling events are required for each human thought, feeling, and perception, the movement of our limbs, and the beat of our hearts. As the initiators of action potentials in excitable tissues, voltage-gated ...
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(2009-03-13)Department: Biological SciencesThe existence of anatomical differences along the left-right (L-R) axis in the brain and visceral organs is an evolutionarily conserved feature of the vertebrate lineage. Although much is known about the molecular pathways ...
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(2012-10-08)Department: Biological SciencesThe adult vertebrate forebrain is responsible for a diverse set of behaviors, and as such exhibits complex anatomy. This complexity is generated during embryogenesis whereby a specific spatiotemporal sequence of transcriptional ...