Search
Now showing items 1-8 of 8
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis
(Nature Communications, 2020-01-16)
Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential ...
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
(Nature Communications, 2020-01-09)
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded ...
REPLY TO TRAN ET AL.: Dimeric KRAS protein-protein interaction stabilizers
(Proceedings of the National Academy of Sciences of the United States of America, 2020-02-18)
Can Mentoring Promote Self-esteem and School Connectedness? An Evaluation of the Mentor-UP Project
(Psychological Inervention, 2020-04)
Research in the United States has shown that youth mentoring is a promising strategy for increasing self-esteem and school connectedness in at-risk youth. There has been little confirmation of those findings internationally. ...
Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility
(Nature Communications, 2020-01-07)
Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. Investigation of the shared genetic basis of these phenotypes in the UK Biobank and ...
Countermanding Perceptual Decision-Making
(iScience, 2020-01-24)
We investigated whether a task requiring concurrent perceptual decision-making and response control can be performed concurrently, whether evidence accumulation and response control are accomplished by the same neurons, ...
Interactive Multiresolution Visualization of Cellular Network Processes
(iScience, 2020-01-24)
Visualization plays a central role in the analysis of biochemical network models to identify patterns that arise from reaction dynamics and perform model exploratory analysis. To facilitate these analyses, we developed ...
Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study
(Nature Communications, 2020-02-03)
Each additional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk of Alzheimer's dementia, while the APOE2 allele is associated with a lower risk of Alzheimer's dementia, it is not yet known ...