Search
Now showing items 1-10 of 36
Two truncating variants in FANCC and breast cancer risk
(Scientific Reports, 2019-08-29)
Fanconi anemia (FA) is a genetically heterogeneous disorder with 22 disease-causing genes reported to date. In some FA genes, monoallelic mutations have been found to be associated with breast cancer risk, while the risk ...
Thermal Perceptual Thresholds are typical in Autism Spectrum Disorder but Strongly Related to Intra-individual Response Variability
(Scientific Reports, 2019-08-29)
Individuals with autism spectrum disorder (ASD) are often reported to exhibit an apparent indifference to pain or temperature. Leading models suggest that this behavior is the result of elevated perceptual thresholds for ...
Cell-specific image-guided transcriptomics identifies complex injuries caused by ischemic acute kidney injury in mice
(Communications Biology, 2019-09-02)
The kidney's inherent complexity has made identifying cell-specific pathways challenging, particularly when temporally associating them with the dynamic pathophysiology of acute kidney injury (AKI). Here, we combine renal ...
Probing the solution structure of the E. coli multidrug transporter MdfA using DEER distance measurements with nitroxide and Gd(III) spin labels
(Scientific Reports, 2019-08-29)
Methodological and technological advances in EPR spectroscopy have enabled novel insight into the structural and dynamic aspects of integral membrane proteins. In addition to an extensive toolkit of EPR methods, multiple ...
Synbiotics suppress colitis-induced tumorigenesis in a colon-specific cancer mouse model
(Plos One, 2019-06-26)
Although synbiotics may be effective in maintaining remission of inflammatory bowel disease, their anticarcinogenic effects are still debated. To address this issue, we evaluated the effects of synbiotics, probiotics, and ...
Evaluation of Synthetic Cytochrome P-450-Mimetic Metalloporphyrins To Facilitate "Biomimetic" Biotransformation of a Series of mGlu(5) Allosteric Ligands
(ACS Omega, 2019-07)
Allosteric ligands within a given chemotype can have the propensity to display a wide range of pharmacology, as well as unexpected changes in GPCR subtype selectivity, typically mediated by single-atom modifications to the ...
Towards A Microbead Occlusion Model of Glaucoma for a Non-Human Primate
(2019-08-09)
Glaucoma is a group of optic neuropathies associated with aging and sensitivity to intraocular pressure (IOP). The disease causes vision loss through the degeneration of retinal ganglion cell neurons and their axons in the ...
Non-contrast power Doppler ultrasound imaging for early assessment of trans-arterial chemoembolization of liver tumors
(Scientific Reports, 2019-09-10)
Trans-arterial chemoembolization (TACE) is an important yet variably effective treatment for management of hepatic malignancies. Lack of response can be in part due to inability to assess treatment adequacy in real-time. ...
Racial/ethnic, age and sex disparities in leukemia survival among adults in the United States during 1973-2014 period
(PLoS One, 2019-08-19)
There has been marked improvement in leukemia survival, particularly among children in recent time. However, the long-term trends in survival among adult leukemia patients and the associated sex and racial survival disparities ...
Multi-scale, numerical modeling of spatio-temporal signaling in cone phototransduction
(2019-07-25)
Mammals have two types of photoreceptors, rods and cones. While rods are exceptionally sensitive and mediate vision at very low illumination levels, cones operate in daylight and are responsible for the bulk of visual ...