Effect of striatal and extrastriatal D2-receptor BP on memory and symptoms of schizotypal personality disorder
Patterson, Katherine A.
:
2007-04
Abstract
The integrity of particular dopaminergic projections via the striato-thalamiccortical
feedback loop potentially influences specialized aspects of cognition and
psychopathology. Research has identified a role for striatal D2 receptors in the cognitive
impairments and psychopathological symptoms associated with disorders of the
schizophrenia spectrum. Recent developments in PET neuroimaging methods currently
permit visualization of D2/D3 receptors in extrastriatal regions. This study evaluated
potential correlations between the regional D2/D3 receptor BP in striatal and extrastriatal
areas and psychopathological symptoms and memory performance. Significant
correlations were observed between particular regions of D2/D3 receptor BP and both
verbal and visual memory sub-scales of the Wechsler Memory Scale-III.