dc.creator | Stocks, Blair Taylor | |
dc.date.accessioned | 2020-08-22T17:23:56Z | |
dc.date.available | 2018-07-24 | |
dc.date.issued | 2016-07-24 | |
dc.identifier.uri | https://etd.library.vanderbilt.edu/etd-07132016-074224 | |
dc.identifier.uri | http://hdl.handle.net/1803/12976 | |
dc.description.abstract | Achieving transplant tolerance in the autoimmune environment will require targeting multiple immunologic dysregulations in T-B lymphocyte collaboration that drive the aggressive anti-graft response. At a biologic level, my findings reveal the necessity of overcoming B lymphocyte mediated restriction of CD4 Treg function, failed HSC mobilization, and enhanced T cell metabolism in achieving transplant tolerance in murine models of Type 1 Diabetes (T1D) and Systemic Lupus Erythematosus (SLE). At a cellular level, my dissertation demonstrates that specific failures in CD4 and CD8 Treg mediated suppression of the effector cell response in autoimmune T1D and SLE contributes to a generalized resistance to transplant tolerance observed in these strains. Overall, identification of and surmounting the key dysregulations in T-B cell collaboration that permit loss of tolerance in autoimmunity will advance the clinical potential of transplantation as a cure for autoimmune disease. | |
dc.format.mimetype | application/pdf | |
dc.subject | T Regulatory Cells | |
dc.subject | Transplantation | |
dc.subject | Autoimmunity | |
dc.subject | Type 1 Diabetes | |
dc.subject | Lupus | |
dc.subject | Tolerance | |
dc.title | Dysregulated T-B Lymphocyte Collaboration in Autoimmunity Poses a Barrier to Transplant Tolerance | |
dc.type | dissertation | |
dc.contributor.committeeMember | Daniel J. Moore | |
dc.contributor.committeeMember | Alvin C. Powers | |
dc.contributor.committeeMember | Edward Sherwood | |
dc.contributor.committeeMember | Luc Van Kaer | |
dc.type.material | text | |
thesis.degree.name | PHD | |
thesis.degree.level | dissertation | |
thesis.degree.discipline | Microbiology and Immunology | |
thesis.degree.grantor | Vanderbilt University | |
local.embargo.terms | 2018-07-24 | |
local.embargo.lift | 2018-07-24 | |
dc.contributor.committeeChair | Amy Major | |