High-sensitivity imaging of magnetic fields from cardiac apex action potential propagation using superconducting quantum interference device (SQUID) microscopy
McBride, Krista Kay
:
2008-07-26
Abstract
In this dissertation, we explore the magnetic fields associated with action potential propagation in the spiral fiber structure of a rabbit’s cardiac apex. We use optical imaging, SQUID microscopy, monodomain and bidomain modeling to analyze the spiral effect on action potential propagation. We found that the spiral structure gives a distinct magnetic imprint that can be reproduced by monodomain and bidomain modeling.
The SQUID microscope has also been improved by implementing a lever mechanism and monolithic SQUID sensors for higher magnetic spatial resolution and sensitivity measurements.