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Molecular Seismology: An inverse problem in nanobiology.

dc.contributor.authorBoczko, Erik M.
dc.contributor.authorHinow, Peter
dc.date.accessioned2006-09-12T19:44:22Z
dc.date.available2006-09-12T19:44:22Z
dc.date.issued2006-09-12T19:44:22Z
dc.identifier.urihttp://hdl.handle.net/1803/153
dc.description.abstractThe density profile of an elastic fiber like DNA will change in space and time as ligands associate with it. This observation affords a new direction in single molecule studies provided that density profiles can be measured in space and time. In fact, this is precisely the objective of seismology, where the mathematics of inverse problems have been employed with success. We argue that inverse problems in elastic media can be directly applied to biophysical problems of fiber-ligand association, and demonstrate that robust algorithms exist to perform density reconstruction in the condensed phase.en
dc.format.extent591674 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherVanderbilt University
dc.relation.ispartofseriesDBMI Technical Reportsen
dc.subjectDNA-protein interactionsen
dc.subjectWave equationen
dc.subjectSingle molecule studiesen
dc.subjectInverse problems (Differential equations)en
dc.subjectDNA-ligand interactionsen
dc.subjectDensity inversionen
dc.subjectDNA binding kineticsen
dc.titleMolecular Seismology: An inverse problem in nanobiology.en
dc.typeTechnical Reporten
dc.description.schoolSchool of Medicine
dc.description.departmentDepartment of Biomedical Informatics


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