Molecular Seismology: An inverse problem in nanobiology.

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dc.contributor.author Boczko, Erik M.
dc.contributor.author Hinow, Peter
dc.date.accessioned 2006-09-12T19:44:22Z
dc.date.available 2006-09-12T19:44:22Z
dc.date.issued 2006-09-12T19:44:22Z
dc.identifier.uri http://hdl.handle.net/1803/153
dc.description.abstract The density profile of an elastic fiber like DNA will change in space and time as ligands associate with it. This observation affords a new direction in single molecule studies provided that density profiles can be measured in space and time. In fact, this is precisely the objective of seismology, where the mathematics of inverse problems have been employed with success. We argue that inverse problems in elastic media can be directly applied to biophysical problems of fiber-ligand association, and demonstrate that robust algorithms exist to perform density reconstruction in the condensed phase. en
dc.format.extent 591674 bytes
dc.format.mimetype application/pdf
dc.language.iso en en
dc.publisher Vanderbilt University
dc.relation.ispartofseries DBMI Technical Reports en
dc.subject DNA-protein interactions en
dc.subject Wave equation en
dc.subject Single molecule studies en
dc.subject Inverse problems (Differential equations) en
dc.subject DNA-ligand interactions en
dc.subject Density inversion en
dc.subject DNA binding kinetics en
dc.title Molecular Seismology: An inverse problem in nanobiology. en
dc.type Technical Report en
dc.description.school School of Medicine
dc.description.department Department of Biomedical Informatics

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