dc.contributor.author | Ghafuri, Djamila L. | |
dc.contributor.author | Abdullahi, Shehu U. | |
dc.contributor.author | Jibir, Binta W. | |
dc.contributor.author | Gambo, Safiya | |
dc.contributor.author | Bello-Manga, Halima | |
dc.contributor.author | Haliru, Lawal | |
dc.contributor.author | Bulama, Khadija | |
dc.contributor.author | Usman, Fahd M. | |
dc.contributor.author | Gambo, Awwal | |
dc.contributor.author | Aliyu, Muktar H. | |
dc.contributor.author | Greene, Brittany C. | |
dc.contributor.author | Kassim, Adetola A. | |
dc.contributor.author | Slaughter, Chris | |
dc.contributor.author | Rodeghier, Mark | |
dc.contributor.author | DeBaun, Michael R. | |
dc.date.accessioned | 2020-11-12T22:55:33Z | |
dc.date.available | 2020-11-12T22:55:33Z | |
dc.date.issued | 2020-01 | |
dc.identifier.citation | Ghafuri, D. L., Abdullahi, S. U., Jibir, B. W., Gambo, S., Bello-Manga, H., Haliru, L., Bulama, K., Usman, F. M., Gambo, A., Aliyu, M. H., Greene, B. C., Kassim, A. A., Slaughter, C., Rodeghier, M., & DeBaun, M. R. (2020). World Health Organization's Growth Reference Overestimates the Prevalence of Severe Malnutrition in Children with Sickle Cell Anemia in Africa. Journal of clinical medicine, 9(1), 119. https://doi.org/10.3390/jcm9010119 | en_US |
dc.identifier.other | eISSN: 2077-0383 | |
dc.identifier.uri | http://hdl.handle.net/1803/16285 | |
dc.description.abstract | Anthropometric indices are widely used to assess the health and nutritional status of children. We tested the hypothesis that the 2007 World Health Organization (WHO) reference for assessment of malnutrition in children with sickle cell anemia (SCA) overestimates the prevalence of severe malnutrition when compared to a previously constructed SCA-specific reference. We applied the WHO and SCA-specific references to children with SCA aged 5-12 years living in northern Nigeria (Primary Prevention of Stroke in Children with SCA in sub-Saharan Africa (SPRING) trial) to determine the difference in prevalence of severe malnutrition defined as body mass index (BMI) Z-score <-3 and whether severe malnutrition was associated with lower mean hemoglobin levels or abnormal transcranial Doppler measurements (>200 cm/s). A total of 799 children were included in the final analysis (median age 8.2 years (interquartile range (IQR) 6.4-10.4)). The application of the WHO reference resulted in lower mean BMI than the SCA-specific reference (-2.3 versus -1.2; p < 0.001, respectively). The use of the WHO reference when compared to the SCA-specific reference population also resulted in a higher prevalence of severe malnutrition (28.6% vs. 6.4%; p < 0.001). The WHO reference significantly overestimates the prevalence of severe malnutrition in children with SCA when compared to an SCA-specific reference. Regardless of the reference population, severe malnutrition was not associated with lower mean hemoglobin levels or abnormal transcranial Doppler (TCD) measurements. | en_US |
dc.description.sponsorship | Research reported in this publication was supported by the National Institutes of Health Grant #1R01NS094041-01 and the Aaron Ardoin Foundation Fund for Sickle Cell Anemia. The sponsor did not have any role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Journal of Clinical Medicine | en_US |
dc.rights | Copyright © 2020 by the authors.
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |
dc.source.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020064/ | |
dc.subject | sickle cell disease | en_US |
dc.subject | growth references | en_US |
dc.subject | severe malnutrition | en_US |
dc.title | World Health Organization's Growth Reference Overestimates the Prevalence of Severe Malnutrition in Children with Sickle Cell Anemia in Africa | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.3390/jcm9010119 | |