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Neurocognitive Effects of Treatment of Pediatric Acute Lymphocytic Leukemia: A Neuroimaging Analysis

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dc.contributor.author Livesay, Kate
dc.date.accessioned 2011-02-06T21:25:35Z
dc.date.available 2011-02-06T21:25:35Z
dc.date.issued 2008-04-04
dc.identifier.uri http://hdl.handle.net/1803/4724
dc.description.abstract Acute Lymphocytic Leukemia (ALL) is the most prevalent form of cancer diagnosed in children. The current survival rate is approximately 85% and has been rising over the last two decades. The standard treatment regimen involves intrathecal chemotherapy in addition to corticosteroid drugs. Intrathecal chemotherapy has been shown to cause neurocognitive effects in executive function and IQ. The current study investigates differences in brain activation patterns that could account for the differences in neurocognitive function observed between ALL survivors and healthy controls. In this study, neurocognitive function of ALL survivors was assessed using a test battery that consisted of the Wechsler Intelligence Test for Children-Fourth Edition (WISC-IV) and the Delis-Kaplan Executive Function System (D-KEFS). ALL survivors showed significant deficits on these tests compared to matched, healthy controls. Survivors demonstrating the poorest performance on this battery participated in the neuroimaging component of the study in which brain activation during an inhibitory control task, the Simon task, was measured using functional magnetic resonance imaging (fMRI). ALL survivors demonstrated a compensatory mechanism of cortical recruitment during the Simon task, while performing worse than their matched, healthy controls. There was a significant difference in activation between survivors and healthy controls in the anterior cingulate cortex (BA 24), as predicted, although no differences were found between groups in the prefrontal cortex. en_US
dc.description.sponsorship Thesis completed in partial fulfillment of the requirements of the Honors Program in Psychological Sciences en_US
dc.language.iso en_US en_US
dc.publisher Vanderbilt University en_US
dc.subject.lcsh Neurosciences en_US
dc.subject.lcsh Lymphoblastic leukemia en_US
dc.subject.lcsh Leukemia in children -- Complications en_US
dc.subject.lcsh Cognition disorders -- Etiology en_US
dc.subject.lcsh Leukemia -- Chemotherapy -- Complications en_US
dc.subject.lcsh Brain -- Magnetic resonance imaging en_US
dc.title Neurocognitive Effects of Treatment of Pediatric Acute Lymphocytic Leukemia: A Neuroimaging Analysis en_US
dc.type Thesis en_US
dc.description.school Vanderbilt University en_US
dc.description.department Psychological Sciences en_US


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