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Neurocognitive Effects of Treatment of Pediatric Acute Lymphocytic Leukemia: A Neuroimaging Analysis

dc.contributor.authorLivesay, Kate
dc.description.abstractAcute Lymphocytic Leukemia (ALL) is the most prevalent form of cancer diagnosed in children. The current survival rate is approximately 85% and has been rising over the last two decades. The standard treatment regimen involves intrathecal chemotherapy in addition to corticosteroid drugs. Intrathecal chemotherapy has been shown to cause neurocognitive effects in executive function and IQ. The current study investigates differences in brain activation patterns that could account for the differences in neurocognitive function observed between ALL survivors and healthy controls. In this study, neurocognitive function of ALL survivors was assessed using a test battery that consisted of the Wechsler Intelligence Test for Children-Fourth Edition (WISC-IV) and the Delis-Kaplan Executive Function System (D-KEFS). ALL survivors showed significant deficits on these tests compared to matched, healthy controls. Survivors demonstrating the poorest performance on this battery participated in the neuroimaging component of the study in which brain activation during an inhibitory control task, the Simon task, was measured using functional magnetic resonance imaging (fMRI). ALL survivors demonstrated a compensatory mechanism of cortical recruitment during the Simon task, while performing worse than their matched, healthy controls. There was a significant difference in activation between survivors and healthy controls in the anterior cingulate cortex (BA 24), as predicted, although no differences were found between groups in the prefrontal cortex.en_US
dc.description.sponsorshipThesis completed in partial fulfillment of the requirements of the Honors Program in Psychological Sciencesen_US
dc.publisherVanderbilt Universityen_US
dc.subject.lcshLymphoblastic leukemiaen_US
dc.subject.lcshLeukemia in children -- Complicationsen_US
dc.subject.lcshCognition disorders -- Etiologyen_US
dc.subject.lcshLeukemia -- Chemotherapy -- Complicationsen_US
dc.subject.lcshBrain -- Magnetic resonance imagingen_US
dc.titleNeurocognitive Effects of Treatment of Pediatric Acute Lymphocytic Leukemia: A Neuroimaging Analysisen_US
dc.description.schoolVanderbilt Universityen_US
dc.description.departmentPsychological Sciencesen_US

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