Neurocognitive Effects of Radiation Therapy in Pediatric Brain Tumor Survivors

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dc.contributor.advisor Compas, Bruce E.
dc.contributor.author Smith, Samantha E.
dc.date.accessioned 2012-05-08T21:28:40Z
dc.date.available 2012-05-08T21:28:40Z
dc.date.issued 2012-03-29
dc.identifier.uri http://hdl.handle.net/1803/5095
dc.description.abstract This study characterizes the neurocognitive late effects of treatment in pediatric brain tumor survivors by examining patterns of executive function, coping, emotional outcomes, and brain activation. We examined associations among these variables and their relationship to prefrontal cortex activation in 20 children and adolescents ages 8 to 16‐ years old who completed treatment for a pediatric brain tumor with 20 healthy controls matched on age and sex. We found partial support for our hypothesis that survivors perform worse than healthy controls on these domains and that activation patterns during executive function tasks differ. No causal relationship among executive function, coping, and emotional outcome variables was found. Findings suggest that neurocognitive deficits in survivors may be associated with impairment in prefrontal cortex integrity. en_US
dc.description.sponsorship Thesis completed in partial fulfillment of the requirements of the Honors Program in Psychological Sciences under the Direction of Prof. Bruce E. Compas. en_US
dc.language.iso en_US en_US
dc.publisher Vanderbilt University en_US
dc.subject.lcsh Stress (Psychology) en_US
dc.subject.lcsh Adjustment (Psychology) en_US
dc.subject.lcsh Cancer in children -- Treatment -- Complications en_US
dc.subject.lcsh Brain -- Cancer -- Treatment -- Complications en_US
dc.subject.lcsh Cognition disorders -- Etiology en_US
dc.title Neurocognitive Effects of Radiation Therapy in Pediatric Brain Tumor Survivors en_US
dc.type Thesis en_US
dc.description.school Vanderbilt University en_US
dc.description.department Psychological Sciences en_US

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