dc.contributor.advisor | Park, Sohee | |
dc.contributor.advisor | Woodman, Geoffrey F. | |
dc.contributor.author | Zhu, Julia | |
dc.date.accessioned | 2014-05-31T16:43:47Z | |
dc.date.available | 2014-05-31T16:43:47Z | |
dc.date.issued | 2014-04-15 | |
dc.identifier.uri | http://hdl.handle.net/1803/6384 | |
dc.description | Exploring the ability of transcranial direct current stimulation to improve performance monitoring and learning rate in schizophrenia. For PSY 295/296: Honors Seminar with Dr. Saylor | en_US |
dc.description.abstract | A reliable and valid neurophysiological index of error-monitoring ability is an eventrelated
potential (ERP) known as “error-related negativity” (ERN), which is evoked following an
error response. Individuals with schizophrenia show error monitoring deficits accompanied by reduced ERN. Error monitoring is mediated in part by the medial-frontal cortex, which has been shown to be abnormal in schizophrenia. Transcranial direct current stimulation (tDCS) is a noninvasive tool for transient modulation of cortical function, which delivers low current to brain areas through small electrodes. In this study, we sought to improve performance monitoring in schizophrenia by delivering tDCS to the medial-frontal area. Ten patients and 10 demographically matched controls participated in a difficult choice target color discrimination task with stop trials that were designed to elicit errors while ERPs were recorded. TDCS was delivered before the cognitive task. After anodal tDCS stimulation, performance monitoring and learning rates were improved in the patients and ERN was increased to measures comparable to healthy controls during the sham condition. These results suggest that tDCS could be used to treat cognitive deficits in schizophrenia, and other neuropsychiatric illnesses with widespread cognitive impairments. | en_US |
dc.description.sponsorship | Thesis completed in partial fulfillment of the requirements of the Honors Program in Psychological Sciences. Under the direction of Dr. Sohee Park and Dr. Geoffrey Woodman | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Vanderbilt University | en_US |
dc.subject | transcranial direct current stimulation | en_US |
dc.subject | schizophrenia | en_US |
dc.subject | performance monitoring | en_US |
dc.subject | noninvasive stimulation | en_US |
dc.subject | learning rate | en_US |
dc.subject.lcsh | Brain stimulation | en_US |
dc.subject.lcsh | Schizophrenia -- Treatment | en_US |
dc.subject.lcsh | Schizophrenia | en_US |
dc.subject.lcsh | Learning | en_US |
dc.title | Effects of Transcranial Direct Current Stimulation (tDCS) on Performance Monitoring and Learning Rate in Schizophrenia | en_US |
dc.title.alternative | Transcranial Direct Current Stimulation in Schizophrenia | en_US |
dc.type | Thesis | en_US |
dc.description.college | College of Arts and Science | en_US |
dc.description.school | Vanderbilt University | en_US |
dc.description.department | Psychology | en_US |