Browsing Research reports by Title
Now showing items 7-26 of 34
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(Acta Neuropathologica Communications, 2022-12-17)Background: This study examined neuropathological findings of patients who died following hospitalization in an intensive care unit with SARS-CoV-2.Methods: Data originate from 20 decedents who underwent brain autopsy ...
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(Frontiers in Immunology, 2019-08-13)Multiple effector layers in the immune system ensure an optimal temporal and spatial distribution of immune defense. Cytotoxic innate lymphoid natural killers (NK) and adaptive CD8(+) T lymphocytes (CTL) interact to elicit ...
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(Journal for Immunotherapy of Cancer, 2019-08-14)Background Prostate cancer is poorly responsive to immune checkpoint inhibition, yet a combination with radiotherapy may enhance the immune response. In this study, we combined radiotherapy with immune checkpoint inhibition ...
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(Research And Practice In Thrombosis And Haemostasis, 2022-10-11)
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(JAIDS- Journal of Acquired Immune Deficiency Syndromes, 2019-03-01)Background: An increasing number of HIV-positive individuals now start antiretroviral therapy (ART) with high CD4 cell counts. We investigated whether this makes restoration of CD4 and CD8 cell counts and the CD4: CD8 ratio ...
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(Journal of the International AIDS Society, 2019-12)Introduction Identification of persons living with human immunodeficiency virus (HIV)-associated tuberculosis (TB) at increased risk for unfavourable TB outcomes would inform efforts to improve such outcomes. We sought to ...
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(Frontiers in Bioengineering and Biotechnology, 2019-09-20)The extensive application of engineered nanomaterial (ENM) in various fields increases the possibilities of human exposure, thus imposing a huge risk of nanotoxicity. Hence, there is an urgent need for a detailed risk ...
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(Open Forum Infectious Diseases, 2019-07)Background. The US National Viral Hepatitis Action Plan depends on additional providers to expand hepatitis C virus (HCV) treatment capacity in order to achieve elimination goals. Clinical pharmacists manage treatment and ...
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(Frontiers in Immunology, 2019-09-25)Our previous studies of protective immunity and pathology against blood stage malaria parasites have shown that not only CD4(+) T cells, but also CD8(+) T cells and macrophages, are important for host defense against blood ...
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(Open Forum Infectiouis Diseases, 2019-12)Background. Community-acquired pneumonia (CAP) is the leading cause of death in children. Identification of reliable bio-markers offers the potential to develop a severity quantitative score to assist in clinical decision-making ...
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(Human Vaccines & Immunotherapeutics, 2019-08-03)Objective: The primary aim of this study is to assess and characterize correlates of human papillomavirus (HPV) vaccine series completion among young adult women evaluated by gynecological (GYN) providers at a single ...
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(NATURE COMMUNICATIONS, 2019-07-09)Fibrosis accompanying wound healing can drive the failure of many different organs. Activated fibroblasts are the principal determinants of post-injury pathological fibrosis along with physiological repair, making them a ...
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(FRONTIERS IN MICROBIOLOGY, 2019-07-23)Acinetobacter baumannii A118, a strain isolated from the blood of an infected patient, is naturally competent and unlike most clinical strains, is susceptible to a variety of different antibiotics including those usually ...
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(Cancer Iinformatics, 2019-04-16)The genome-wide identification of mutated genes is an important advance in our understanding of tumor biology, but several fundamental questions remain open. How do these genes act together to promote cancer development ...
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Intestinal epithelial cell-derived components regulate transcriptome of Lactobacillus rhamnosus GG (Frontiers In Microbiology, 2023-01-04)IntroductionIntestinal epithelial cells (IECs) provide the frontline responses to the gut microbiota for maintaining intestinal homeostasis. Our previous work revealed that IEC-derived components promote the beneficial ...
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(Scientific Reports, 2019-07-16)As a class, 'BET' inhibitors disrupt binding of bromodomain and extra-terminal motif (BET) proteins, BRD2, BRD3, BRD4 and BRDT, to acetylated histones preventing recruitment of RNA polymerase 2 to enhancers and promoters, ...
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(Journal of Infectious Diseases, 2020-03-01)Background. Multiple factors influence the human immunodeficiency virus (HIV) antibody response produced during natural infection, leading to responses that can vary in specificity, strength, and breadth. Methods. People ...
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(MBIO, 2019-05)Helicobacter pylori is the strongest risk factor for gastric adenocarcinoma; however, most infected individuals never develop this malignancy. Strain-specific microbial factors, such as the oncoprotein CagA, as well as ...
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(The Journal of Infectious Diseases, 2019-08-01)Metabolic complications relating to complex effects of viral and immune-mediated mechanisms are now a focus of clinical care among persons living with human immunodeficiency virus (PLHIV), and obesity is emerging as a ...
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(MBIO, 2019-07)Phylosymbiosis is defined as microbial community relationships that recapitulate the phylogeny of hosts. As evidence for phylosymbiosis rapidly accumulates in different vertebrate and invertebrate holobionts, a central ...