Search
Now showing items 21-30 of 34
lBromodomain inhibitor JQ1 reversibly blocks IFN-gamma production
(Scientific Reports, 2019-07-16)
As a class, 'BET' inhibitors disrupt binding of bromodomain and extra-terminal motif (BET) proteins, BRD2, BRD3, BRD4 and BRDT, to acetylated histones preventing recruitment of RNA polymerase 2 to enhancers and promoters, ...
TSLP and IL-33 reciprocally promote each other's lung protein expression and ILC2 receptor expression to enhance innate type-2 airway inflammation
(Allergy, 2020-02)
Background The epithelial cell-derived danger signal mediators thymic stromal lymphopoietin (TSLP) and IL-33 are consistently associated with adaptive Th2 immune responses in asthma. In addition, TSLP and IL-33 synergistically ...
Fluctuations of Spleen Cytokine and Blood Lactate, Importance of Cellular Immunity in Host Defense Against Blood Stage Malaria Plasmodium yoelii
(Frontiers in Immunology, 2019-09-25)
Our previous studies of protective immunity and pathology against blood stage malaria parasites have shown that not only CD4(+) T cells, but also CD8(+) T cells and macrophages, are important for host defense against blood ...
Identification of Potential Virulence Factors in the Model Strain Acinetobacter baumannii A118
(FRONTIERS IN MICROBIOLOGY, 2019-07-23)
Acinetobacter baumannii A118, a strain isolated from the blood of an infected patient, is naturally competent and unlike most clinical strains, is susceptible to a variety of different antibiotics including those usually ...
Interchromosomal Translocations as a Means to Map Chromosome Territories in Breast Cancer
(Cancer Iinformatics, 2019-04-16)
The genome-wide identification of mutated genes is an important advance in our understanding of tumor biology, but several fundamental questions remain open. How do these genes act together to promote cancer development ...
Obesity and Fat Metabolism in Human Immunodeficiency Virus-Infected Individuals: Immunopathogenic Mechanisms and Clinical Implications
(The Journal of Infectious Diseases, 2019-08-01)
Metabolic complications relating to complex effects of viral and immune-mediated mechanisms are now a focus of clinical care among persons living with human immunodeficiency virus (PLHIV), and obesity is emerging as a ...
Age-Related Differences in Hospitalization Rates, Clinical Presentation, and Outcomes Among Older Adults Hospitalized With Influenza-US Influenza Hospitalization Surveillance Network (FluSurv-NET)
(2019-07)
Background. Rates of influenza hospitalizations differ by age, but few data are available regarding differences in laboratory-confirmed rates among adults aged >= 65 years.
Methods. We evaluated age-related differences ...
The Anti-Proliferative and Anti-Invasive Effect of Leaf Extracts of Blueberry Plants Treated with Methyl Jasmonate on Human Gastric Cancer In Vitro Is Related to Their Antioxidant Properties
(Antioxidants, 2020-01)
Gastric cancer is the third main cause of cancerous tumors in humans in Chile. It is well-accepted that a diet rich in antioxidant plants could help in fighting cancer. Blueberry is a fruit crop with a high content of ...
Atypical Clinical Manifestations of Loiasis and Their Relevance for Endemic Populations
(Open Forum Infectious Diseases, 2019-11)
Background. Loiasis is mostly considered a relatively benign infection when compared with other filarial and parasitic diseases, with Calabar swellings and eyeworm being the most common signs. Yet, there are numerous reports ...
Host Inflammatory Biomarkers of Disease Severity in Pediatric Community-Acquired Pneumonia: A Systematic Review and Meta-analysis
(Open Forum Infectiouis Diseases, 2019-12)
Background. Community-acquired pneumonia (CAP) is the leading cause of death in children. Identification of reliable bio-markers offers the potential to develop a severity quantitative score to assist in clinical decision-making ...