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Now showing items 31-40 of 50
RSKy Business in the Mammary Gland
(2018-04-11)
The family of ribosomal S6 Ser/Thr protein kinases (RSK) controls proliferation, viability and motility and, therefore, contributes to the etiology of numerous cancers, including breast. We found that RSK2 is an obligate ...
Pathway Exploration for Breast Cancer Care
(2017-05-30)
Pathway exploration can support clinical research efforts and shared decision making between providers, patients, and their families. In this work, we extend the Pathfinder temporal abstraction method and developed a ...
Assessing Treatment Response of HER2+ Breast Cancer Xenografts with PET and MRI
(2013-07-29)
With the development of anti-cancer therapies that specifically target the tumor and its microenvironment, the current radiographic analysis of treatment response that uses one-dimensional changes in tumor size may not be ...
The Function of MTBP in Proliferation, Tumorigenesis and Tumor Cell Maintenance
(2014-07-22)
Although the MYC transcription factor was discovered over three decades ago and is dysregulated in the majority of human cancers, its regulation remains incompletely understood and there is no pharmacologic means to inhibit ...
Temporal Abstraction for Generating Quality Metrics for Breast Cancer Treatment
(2015-08-03)
Monitoring quality metrics continuously in breast cancer care can help healthcare providers and organizations engage with patients, advance the delivery of care, and tackle financial challenges. In this work, we develop ...
Development of prognostic model for breast cancer in Shanghai Breast Cancer Survival Study (SBCSS)
(2015-07-23)
We developed prognostic models to predict five-year overall survival (OS), ten-year overall survival (OS), and five-year relapse-free survival (RFS) from Shanghai Breast Cancer Survival Study (SBCSS). SBCSS is a large, ...
Role of TGF-β signaling in carcinoma cell migration and tumor progression
(2012-07-26)
Transforming growth factor-beta (TGF-β) has a dual role during tumor progression initially as a suppressor and then as a promoter. Much is known about the contribution of TGF-β signaling to tumorigenesis, yet, the role ...
Learning the State of Patient Care and Opportunities for Improvement from Electronic Health Record Data with Applications in Breast Cancer Patients
(2017-04-17)
Patient care is complex and imperfect. Understanding and improving patient care requires clinical datasets and scientific methodology. We designed a set of methods to characterize the state of patient care and identify ...
The role of mTORC2 in mammary morphogenesis and HER2-mediated tumorigenesis
(2015-07-09)
CANCER BIOLOGY
The role of mTORC2 in mammary morphogenesis
and HER2-mediated tumorigenesis
Meghan Melinda Morrison
Dissertation under the direction of Professor Rebecca Cook
The phosphatidyl inositol-3-kinase (PI3K)/Akt ...
Imaging of Osteolytic Breast Cancer Metastases with Computed Tomography, Positron Emission Tomography and Single Photon Emission Computed Tomography
(2010-04-12)
Imaging protocols for detection of breast cancer metastases to bone in clinical imaging have long been standardized, but to date small animal imaging still uses a variety of imaging modalities and protocols. Although imaging ...