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The Role of the Prostaglandin E2 EP3 Receptor in Obesity, Insulin Resistance, and Glycemic Control
(2015-12-01)
Mice carrying a targeted disruption of the prostaglandin E2 E-prostanoid receptor 3 (EP3) gene, Ptger3, were fed a high-fat diet (HFD), or a micronutrient matched control diet, to investigate the effects of disrupted ...
“I’m The One That Understands What’s Happening To Me”: Sensemaking Narratives of People with Type I Diabetes
(2017-12-08)
While healthcare research has examined how social and emotional factors complicate treatment of chronic disease, practitioners often have few resources to assess and address the impact of non-biological influences on patient ...
The multifaceted role of eosinophils in adipose tissue: from metabolism to allergy
(2017-12-12)
Obesity has reached epidemic proportions worldwide, with some of the greatest severity in the United States. The most recent data reports ~70% of the American population is overweight (BMI ≥ 25 kg/m2) and ~35% obese (BMI ...
Regulation of insulin resistance by Cyp2c44-derived lipids
(2016-11-22)
Type 2 diabetes affects 10% of the United States population, and patients with diabetes have an increased risk for diseases such as atherosclerosis and hypertension. Since all these diseases are associated with insulin ...
Dopaminergic regulation of insulin secretion from the pancreatic islet
(2012-12-11)
Insulin secretion is the natural response to hyperglycemia, and it is crucial to maintain glucose homeostasis in healthy individuals. Impairment in this regulation eventually results in Type-2 diabetes. From the perspective ...
Transcriptional Profiling of Pancreatic Progenitor Cells
(2011-12-04)
Pluripotent stem cells, because of their ability to differentiate into any cell type, have been widely advocated as a means of producing a nearly unlimited source of new insulin-producing β cells for the treatment of ...
The role of leptin in macrophage-driven aortic root lesion formation and of macrophage inflammatory protein-1α in leukocyte infiltration of white adipose tissue
(2009-12-11)
Obesity is a strong risk factor for type 2 diabetes and cardiovascular disease partly because of the changes that occur in white adipose tissue (WAT) during weight gain. As obesity progresses, WAT expands, becomes ...
Development of Optical Imaging Methods for Evaluating the Vascular Response to Hind Limb Ischemia
(2015-11-23)
Peripheral arterial disease (PAD) affects millions of individuals and increases the risk of myocardial infarction, stroke, and mortality. Compared to the general population, diabetic patients have a four times greater risk ...
Tissue-specific regulation and function of Pancreatic and duodenal homeobox 1
(2006-12-04)
The transcription factor Pancreatic and duodenal homeobox 1 (Pdx1) is essential for formation of the pancreas and for glucose-responsive insulin secretion from mature pancreatic beta cells. In humans and mice, heterozygosity ...
Gene expression and copy number variation in common complex diseases
(2010-12-17)
Common, complex diseases are not caused by a single gene mutation but rather have genetic and environmental components. As a subset, autoimmune diseases also possess robust gene expression signatures that have both genetic ...