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Role of Invariant Natural Killer T Cells in Tularemia-like Disease in Mice
(2015-11-13)
The respiratory mucosa is a major site for pathogen invasion and, hence, a site requiring constant immune surveillance. The type I, semi-invariant natural killer T (iNKT) cells are enriched within the lung vasculature. ...
NF-kappa B signaling and inflammasome activation in developing fetal lung macrophages
(2014-12-31)
Bronchopulmonary dysplasia is a life-threatening lung disease affecting low birth weight preterm infants. While the occurrence of BPD is correlated with chorioamnionitis, the origination and pathway of fetal lung inflammation ...
The Role of the Prostaglandin E2 EP3 Receptor in Obesity, Insulin Resistance, and Glycemic Control
(2015-12-01)
Mice carrying a targeted disruption of the prostaglandin E2 E-prostanoid receptor 3 (EP3) gene, Ptger3, were fed a high-fat diet (HFD), or a micronutrient matched control diet, to investigate the effects of disrupted ...
The role of Y1R-expressing dorsal horn interneurons in pain
(2011-12-20)
The spinal Neuropeptide Y (NPY) system is a potential target for development of new pain therapeutics. NPY and two of its receptors (Y1 and Y2) are found in the superficial dorsal horn of the spinal cord, a key area of ...
The multifaceted role of eosinophils in adipose tissue: from metabolism to allergy
(2017-12-12)
Obesity has reached epidemic proportions worldwide, with some of the greatest severity in the United States. The most recent data reports ~70% of the American population is overweight (BMI ≥ 25 kg/m2) and ~35% obese (BMI ...
TGFbeta signaling enhances wound healing inflammation in post-partum breast cancer.
(2014-12-02)
Breast cancer is the leading cancer diagnosis in pre-menopausal women in the U.S. Of these breast cancers, 25% are diagnosed 2-5 years post-partum. Unfortunately, post-partum breast cancers (ppBCs) are highly metastatic. ...
The Role of Factor XI During Murine Polymicrobial Sepsis
(2016-11-21)
Sepsis is a systemic inflammatory response to infection. It is often accompanied by the pathologic production of thrombin, the key enzyme in blood plasma responsible for coagulation, and by contact activation, which is a ...
The role of Nuclear Factor-kappa B (NF-kB) in the regulation of lung inflammation.
(2004-12-01)
The NF-kappaB pathway has been shown to play a critical role in both adaptive and innate immunity and has been implicated as a focal point for induction of lung inflammation by a variety of inflammatory stimuli; however, ...
MyD88: central relay station of Interleukin 1 signaling pathway
(2005-12-13)
As inflammation is a major mechanism of disease, we investigated the signal transduction processes induced by the key inflammatory cytokine Interleukin (IL) 1 beta as well as the genome responses to pathogen-derived ...
The Pathologic Continuum of Plasmin Activity in Severe Injury
(2021-12-21)
Severe injury is a leading cause of death and disability worldwide, affecting over 3 million individuals in the U.S. yearly. Early complications of severe injury include bleeding, thrombosis and organ dysfunction, and if ...