Browsing Electronic Theses and Dissertations by Title
Now showing items 2942-2961 of 6988
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(2010-06-16)Department: BiochemistryAfter 30 years of research, p53 is recognized as one of the most frequently mutated genes in human cancer (Baker et al, 1989; Nigro et al, 1989; Momand et al, 2000; Daujat et la, 2001). To accomplish its tumor suppressive ...
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(2021-11-19)Department: Biomedical InformaticsClinical prediction models are increasingly common, particularly with advances in machine learning. Assigning outcome labels on which to train these models is challenging due to the time-consuming and resource-intensive ...
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(2006-12-07)Department: BiochemistryBIOCHEMISTRY IDENTIFICATION AND REGULATION OF P53 TARGET GENES IN PRIMARY HUMAN EPIDERMAL KERATINOCYTES KRISTY L. SCHAVOLT Dissertation under the direction of Professor Jennifer A. Pietenpol The p53 tumor suppressor ...
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Identification and Scoring of Partial Covalent Interactions in Proteins and Protein Ligand Complexes (2013-12-16)Department: ChemistryPartial covalent interactions (PCI) such as hydrogen bonds, salt bridges, cation-π, and π-π interactions contribute to protein thermostability. Algorithms that identify PCIs rely on pairwise atom-atom angles and distances, ...
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(2017-04-04)Department: Cell and Developmental BiologyApico-basolateral polarity is a fundamental property of epithelial cells, and its loss is a hallmark of colorectal cancer (CRC). Role(s) for lateral integrins in this polarization process and the consequences of their ...
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(2005-07-18)Department: Cell and Development BiologyFertilization is a complex process involving several steps, including sperm activation, oocyte maturation, chemotaxis, gamete recognition, and cell fusion. Many of these essential steps are controlled and regulated by ...
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(2010-08-04)Department: Interdisciplinary Studies: Applied StatisticsMultiple sclerosis (MS) is characterized as an autoimmune neurodegenerative disease. The disease manifests as demyelination or degradation of the myelin sheath in the central nervous system. The Major Histocompatibility ...
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(2008-08-04)Department: Molecular Physiology and BiophysicsBone morphogenetic protein 4 (Bmp4) is a multi-functional, developmentally regulated gene and is essential for early mouse development. Little is known about the transcriptional regulation of Bmp4. To investigate the ...
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(2021-05-13)Department: Cell & Developmental BiologyThe body of work presented in this dissertation details the characterization of a novel human-cell derived model of the understudied, non-canonical cullin scaffold CUL9. Unlike other cullins, previous efforts to characterize ...
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(2013-11-25)Department: NeuroscienceEpilepsy is a neurological disorder affecting approximately 3 million Americans. Two-thirds of patients diagnosed with epilepsy have no known cause for their disease, however recent evidence suggests most result from complex ...
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(2016-03-30)Department: BiochemistryClostridium difficile is the leading cause of hospital-acquired diarrhea in the United States. The two main virulence factors of C. difficile are the large toxins, TcdA and TcdB, which enter colonic epithelial cells and ...
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(2023-08-14)Department: Molecular Physiology & BiophysicsThis thesis identifies the molecular and physiological targets downstream of glucagon-like peptide-1 receptor (GLP-1R) activation that promote the weight-lowering effect of GLP-1R agonists. The first project builds on ...
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(2009-02-10)Department: Microbiology and ImmunologyUncoating of the viral core following penetration into the target cell represents a fundamentally obscure step in the HIV-1 life cycle. Our laboratory has previously reported that mutations in the CA protein that positively ...
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(2015-07-21)Department: Cancer BiologyCancer is the second leading cause of death in the United States. It is important to identify novel drivers of cancer in order to understand these diseases so we can improve patient prognosis. This dissertation focuses ...
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(2015-03-06)Department: Cancer BiologySolid tumor treatment paradigms have drastically improved in recent decades through direct targeting of the protein products of somatic, constitutively active “driver” mutations and their effector signaling pathways. Prior ...
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(2021-07-21)Department: Interdisciplinary Materials ScienceAs Moore’s Law scaling has pushed the limits of transistor fabrication to sub-10 nm, researchers and engineers have broadened approaches for achieving increased performance in semiconductor devices to include vertical and ...
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(2009-04-09)Department: BiochemistryThis study demonstrated the utility of direct tissue MALDI MS in identifying early markers of antibiotic induced nephrotoxicity. Using a histology directed approach, twelve proteins were identified as having statistically ...
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(2009-09-29)Department: NeuroscienceGliomas are the predominant type of primary central nervous system tumors. They are highly invasive and notoriously refractory to current therapies. Patients diagnosed with a malignant glioma face a dismal prognosis that ...
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(2023-01-23)Department: Mechanical EngineeringWhile the functionality and safety of lower limb prostheses has improved in recent decades, a notable deficit remains when recovering from a trip or stumble. Transfemoral prosthesis users are at a substantially heightened ...
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(2020-08-18)Department: Biomedical InformaticsThe improper regulation of gene expression is a main cause of complex disease. Non-coding single nucleotide variants influence disease risk by altering gene regulatory elements, such as promoters and enhancers. In addition ...