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Novel Biochemical Regulatory Mechanisms of Developmental Signaling Pathways
(2014-12-19)
The Notch signaling pathway is an essential cell-cell signaling pathway that is involved in cell fate decisions and cell differentiation during early metazoan development. In humans, the Notch pathway is misregulated in ...
Mother-Child Communication About Cancer: The Role of Maternal Anxiety and Coping
(2010-01-04)
The objective of the study was to 1) understand the inter-relationships among variables of mother-child communication, maternal distress and illness-related stressors and 2) to isolate maternal distress and coping behaviors ...
Development of combined Raman spectroscopy - optical coherence tomography for the detection of skin cancer
(2009-12-23)
Skin cancer is the most common cancer in the United States, with an incidence rate that continues to rise. Fortunately, it can be highly curable if detected at an early stage. Best clinical practices require physicians to ...
Mechanisms of Cisplatin Resistance in Triple Negative Breast Cancer
(2014-11-26)
Genomic instability and deregulated proliferation are hallmarks of human tumors. Cytotoxic chemotherapeutics, including cisplatin, have been used for over forty years to combat cancers that have deregulated proliferation ...
Development, Optimization and Evaluation of Tumor-Specific Nanosponge Drug Delivery Systems as Chemotherapeutics
(2014-12-03)
Current chemotherapeutic treatments for cancer utilize systemic administration of cytotoxic drugs and produce many side effects in healthy tissues, making optimal treatment of cancer hard to achieve. Tumor targeted ...
Quantifying Cellular Heterogeneity in Cancer and the Microenvironment
(2016-11-29)
In spite of recent advances in therapy, cancer remains a leading cause of death worldwide. Therapy response is often unpredictable and relapse frequently occurs. In many cases, this therapy resistance is attributed to ...
Effect of MAPK inhibition on cell cycle regulation of thymidine kinase 1 and [18F]-FLT PET
(2009-12-14)
Positron emission tomography (PET) imaging using the radiotracer 3’-deoxy-3’-[18F]fluorothymidine ([18F]-FLT) has shown potential as a biomarker of proliferation in tumors. [18F]-FLT measures the activity of thymidine ...
Identification of Novel Targets for Therapy in Solid Tumors
(2015-03-06)
Solid tumor treatment paradigms have drastically improved in recent decades through direct targeting of the protein products of somatic, constitutively active “driver” mutations and their effector signaling pathways. Prior ...
Folate-targeted proteolytic nanobeacons: towards selective, imaged delivery in solid tumors
(2014-11-26)
Cancer, a diagnosis that encompasses over 200 different disease states classified as malignant neoplasms, is poised to become the leading cause of death in the United States. Many of these diseases arise in the form of ...
The Role of VAPB in Breast Cancer
(2012-12-07)
VAPB (VAMP-associated protein B) is an endoplasmic reticulum protein that regulates multiple biological functions. VAPB protein expression is elevated in human breast cancers and correlates with poor prognosis. Despite ...