Search
Now showing items 1-10 of 12
Cardiolipin-Dependent Properties of Model Mitochondrial Membranes from Molecular Simulations
(Biophysical Journal, 2019-08)
Cardiolipin is an anionic lipid found in the mitochondrial membranes of eukaryotes ranging from unicellular microorganisms to metazoans. This unique lipid contributes to various mitochondrial functions, including metabolism, ...
Multiplexed Adaptive RT-PCR Based on L-DNA Hybridization Monitoring for the Detection of Zika, Dengue, and Chikungunya RNA
(Scientific Reports, 2019-08-06)
Reverse transcription polymerase chain reaction (RT-PCR) is the gold standard for the molecular diagnosis of many infectious diseases, including RNA viruses, but is generally limited to settings with access to trained ...
Identification of drug-specific public TCR driving severe cutaneous adverse reactions
(Nature Communications, 2019-08-08)
Drug hypersensitivity such as severe cutaneous adverse reactions (SCAR), including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), could be life-threatening. Here, we enroll SCAR patients to investigate ...
Essentialism and Enhancing Healthcare Experiences: The Strategic Pursuit of "Less"
(Journal of Patient Experience, 2019-06)
Salidroside inhibits the proliferation and migration of gastric carcinoma cells and tumor growth via the activation of ERS-dependent autophagy and apoptosis
(RSC Advances, 2019-08-18)
The endoplasmic reticulum stress (ERS)-induced autophagy and apoptosis are favorable for the suppression of many cancer types. Salidroside (Salid) has been proven to be capable of inducing the apoptosis of many cancer ...
Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response
(Nature Communications, 2019-07-22)
Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality in infants <2 years-old. Here we describe that high-fiber diet protects mice from RSV infection. This effect was dependent on ...
Akt Signaling in Macrophage Polarization, Survival, and Atherosclerosis
(International Journal of Molecular Sciences, 2019-06-01)
The PI3K/Akt pathway plays a crucial role in the survival, proliferation, and migration of macrophages, which may impact the development of atherosclerosis. Changes in Akt isoforms or modulation of the Akt activity levels ...
A human memory circuit derived from brain lesions causing amnesia
(NATURE COMMUNICATIONS, 2019-08-02)
Human memory is thought to depend on a circuit of connected brain regions, but this hypothesis has not been directly tested. We derive a human memory circuit using 53 case reports of strokes causing amnesia and a map of ...
Methylmercury exposure, genetic variation in metabolic enzymes, and the risk of glioma
(Scientific Reports, 2019-07-26)
Methylmercury (MeHg) is an environmental neurotoxin with human exposure mainly from dietary intake of contaminated fish. Exposure to MeHg has been implicated in neurological damage, but research on its role in cancers, ...
Automated cell boundary and 3D nuclear segmentation of cells in suspension
(Scientific Reports, 2019-07-15)
To characterize cell types, cellular functions and intracellular processes, an understanding of the differences between individual cells is required. Although microscopy approaches have made tremendous progress in imaging ...