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Deletion of Tet proteins results in quantitative disparities during ESC differentiation partially attributable to alterations in gene expression
(BMC Developmental Biology, 2019-07-08)
BackgroundThe Tet protein family (Tet1, Tet2, and Tet3) regulate DNA methylation through conversion of 5-methylcytosine to 5-hydroxymethylcytosine which can ultimately result in DNA demethylation and play a critical role ...
Diaspora linkages benefit both sides: a single partnership experience
(Global Health Action, 2019-01)
The emigration of physicians and scientists from resource-constrained countries decreases the country's ability to undertake research. Re-establishing research environments and increasing capacity reduced by these losses ...
Correlated evolution between repertoire size and song plasticity predicts that sexual selection on song promotes open-ended learning
(eLife, 2019-09-03)
Some oscine songbird species modify their songs throughout their lives ('adult song plasticity' or 'open-ended learning'), while others crystallize their songs around sexual maturity. It remains unknown whether the strength ...
Microtubule minus-end stability is dictated by the tubulin off-rate
(Journal of Cell Biology, 2019-09)
Dynamic organization of microtubule minus ends is vital for the formation and maintenance of acentrosomal microtubule arrays. In vitro, both microtubule ends switch between phases of assembly and disassembly, a behavior ...
USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification
(Cell Reports, 2019-07-23)
The WNT signaling network is comprised of multiple receptors that relay various input signals via distinct transduction pathways to execute multiple complex and context-specific output processes. Integrity of the WNT ...
CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease
(Aging Cell, 2019-08)
CpG-related single nucleotide polymorphisms (CGS) have the potential to perturb DNA methylation; however, their effects on Alzheimer disease (AD) risk have not been evaluated systematically. We conducted a genome-wide ...
Point mutations in the PDX1 transactivation domain impair human beta-cell development and function
(Molecular Metabolism, 2019-06)
Objective: Hundreds of missense mutations in the coding region of PDX1 exist; however, if these mutations predispose to diabetes mellitus is unknown.
Methods: In this study, we screened a large cohort of subjects with ...