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Myeloid Cell-Derived HB-EGF Drives Tissue Recovery After Pancreatitis
(Cellular and Molecular Gastroenterology and Hepatology, 2019)
BACKGROUND & AIMS: Pancreatitis is a major cause of morbidity and mortality and is a risk factor for pancreatic tumorigenesis. Upon tissue damage, an inflammatory response, made up largely of macrophages, provides multiple ...
Enteropathogenic Escherichia coli remodels host endosomes to promote endocytic turnover and breakdown of surface polarity
(PLOS Pathogens, 2019-06)
Enteropathogenic E. coli (EPEC) is an extracellular diarrheagenic human pathogen which infects the apical plasma membrane of the small intestinal enterocytes. EPEC utilizes a type III secretion system to translocate bacterial ...
Structural state recognition facilitates tip tracking of EB1 at growing microtubule ends
(eLIFE, 2019-09-03)
The microtubule binding protein EB1 specifically targets the growing ends of microtubules in cells, where EB1 facilitates the interactions of cellular proteins with microtubule plus-ends. Microtubule end targeting of EB1 ...
Regulation of the Pancreatic Exocrine Differentiation Program and Morphogenesis by Onecut 1/Hnf6
(Cellular and Molecular Gastroenterology and Hepatology, 2019)
BACKGROUND & AIMS: The Onecut 1 transcription factor (Oc1, a.k.a. HNF6) promotes differentiation of endocrine and duct cells of the pancreas; however, it has no known role in acinar cell differentiation. We sought to better ...
Targeting WDR5: A WINning Anti-Cancer Strategy?
(EPIGENETICS INSIGHTS, 2019-07-18)
WDR5 is a component of multiple epigenetic regulatory complexes, including the mixed lineage leukemia (MLL)/SET complexes that deposit histone H3 lysine 4 methylation. Inhibitors of an arginine-binding cavity in WDR5, known ...
Deletion of Tet proteins results in quantitative disparities during ESC differentiation partially attributable to alterations in gene expression
(BMC Developmental Biology, 2019-07-08)
BackgroundThe Tet protein family (Tet1, Tet2, and Tet3) regulate DNA methylation through conversion of 5-methylcytosine to 5-hydroxymethylcytosine which can ultimately result in DNA demethylation and play a critical role ...
Diaspora linkages benefit both sides: a single partnership experience
(Global Health Action, 2019-01)
The emigration of physicians and scientists from resource-constrained countries decreases the country's ability to undertake research. Re-establishing research environments and increasing capacity reduced by these losses ...
Correlated evolution between repertoire size and song plasticity predicts that sexual selection on song promotes open-ended learning
(eLife, 2019-09-03)
Some oscine songbird species modify their songs throughout their lives ('adult song plasticity' or 'open-ended learning'), while others crystallize their songs around sexual maturity. It remains unknown whether the strength ...
Microtubule minus-end stability is dictated by the tubulin off-rate
(Journal of Cell Biology, 2019-09)
Dynamic organization of microtubule minus ends is vital for the formation and maintenance of acentrosomal microtubule arrays. In vitro, both microtubule ends switch between phases of assembly and disassembly, a behavior ...
USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification
(Cell Reports, 2019-07-23)
The WNT signaling network is comprised of multiple receptors that relay various input signals via distinct transduction pathways to execute multiple complex and context-specific output processes. Integrity of the WNT ...