Browsing by Title
Now showing items 1584-1603 of 17412
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(2014-03-21)Department: ChemistryOver the course of billions of years, nature has developed incredible materials on the nanoscale for the efficient conversion of solar energy into chemical energy. One of these materials, Photosystem I (PSI), functions as ...
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(2009-08-11)Department: ChemistryThe use of fluorescent microscopy as a tool for studying biological systems has exploded with the development of the laser scanning confocal microscope. In conjunction with traditional biochemical techniques, it can plan ...
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(2010-04-12)Department: Cell and Developmental BiologyColorectal cancer is the second most lethal, non-cutaneous epithelial cancer in the United States. Metastasis contributes to the majority of cancer-related deaths in this disease. Metastasis closely resembles the ...
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(2005-02-03)Department: Biomedical EngineeringCell encapsulation is a novel therapeutic approach for the treatment of Type I Diabetes Mellitus that circumvents both the immunosuppression and limited allograft donor source dilemma. Current methods for scoring the ...
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(2023-11-17)Department: Molecular Pathology & ImmunologyGenomic and transcriptomic analysis have revolutionized our understanding of many cancers. However, genomic understanding of thyroid cancer has lagged behind other tumors; currently, thyroid cancer management is largely ...
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(2012-12-12)Department: PhysicsDorsal closure is an important morphogenetic event in the embryogenesis of Drosophila melanogaster and serves as a useful model system for studying wound healing, palatogenesis, and neural tube closure in vertebrates. ...
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(2018-11-08)Department: Biomedical EngineeringChemical and biomedical sciences depend heavily on interaction assays, particularly those providing structural insights. This dissertation shows that free-solution, label-free studies report molecular conformation and ...
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(Vanderbilt News Service, 2005-11-15)
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(2006-12-13)Department: ChemistryCurrent approaches to the synthesis of metal oxides generally require harsh conditions. In contrast, many biological processes can produce intricate metal oxide nanostructures under ambient conditions. For example, the ...
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(Proceedings of the National Academy of Sciences of the United States of America, 2019-09-03)Crystallization by particle attachment (CPA) of amorphous precursors has been demonstrated in modern biomineralized skeletons across a broad phylogenetic range of animals. Precisely the same precursors, hydrated (ACC-H2O) ...
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(2014-04-01)Department: ChemistryIon mobility-mass spectrometry (IM-MS) applies a gas-phase separation on the basis of structure prior to the MS, enabling separation of different types of biomolecules based on their gas-phase packing efficiencies. For ...
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(2007-12-05)Department: PhysicsThe aim of the research described in this thesis was to study basic mechanisms of functional magnetic resonance imaging (fMRI) and to develop an improved understanding of the Blood Oxygen Level Dependent (BOLD) effect. In ...
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(2007-12-07)Department: PhysicsIn the research described, we developed methods and protocols for high-spatial resolution functional magnetic resonance imaging (fMRI) of cortical activity in the brains of anesthetized non-human primates with sub-millimeter ...
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(2018-03-26)Department: Chemical EngineeringT-lymphocytes use their surface T-cell receptors (αβTCRs) to recognize sparse antigenic peptides bound to MHC molecules (pMHC) arrayed on antigen presenting cells (APCs). Both T-cell movements and cytoskeletal rearrangements ...
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(2018-09-20)Department: PhysicsThis work applies novel inverse modeling techniques to both chemical kinetics in lab-on-chip devices and cell mechanics in developing Drosophila embryos. The aim is to describe these systems quantitatively; to compare ...
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(2013-12-03)Department: BiochemistryEngineered biocatalysts have become increasingly sought after as replacements for individual chemical synthetic steps. However, their implementation in multistep sequences as biosynthetic pathways has proven to be a ...
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Biosynthetic Derivatization of Antimicrobial Orthosomycins to Engage a Unique Ribosomal Binding Site (2021-02-19)Department: ChemistryAntimicrobial resistance is a critical threat to human health that results in an estimated 100,000 deaths in the United States each year, according to the World Health Organization. This growing crisis demands the development ...
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(2011-02-17)Department: ChemistryThe dissertation contained herein describes biosynthetic investigations of the peptide natural products K-26 and anthramycin. Unified by their peptidic nature, K 26 and anthramycin are potent biologically active metabolites ...
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(2013-09-19)Department: PharmacologyBiosynthesis of lipid mediators including the leukotrienes, lipoxins, eoxins, resolvins, and protectins entails the lipoxygenase (LOX) catalyzed synthesis of an allylic epoxide intermediate, designated as leukotriene A4 ...
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(2008-06-24)Department: ChemistryMass spectrometry is a powerful technique that can be used at every stage of natural product studies, from discovery and structural characterization of new compounds to biosynthetic enzyme identification and manipulation. ...