My thesis project explores mechanisms controlling CD8+ T cell impairment in the lung during viral acute lower respiratory infection. I show that viral infection is required for lung T cell impairment and that cognate viral ...

Diabetes mellitus affects approximately 150 million people worldwide. This disease is characterized by hyperglycemia resulting from dysfunctional pancreatic beta cells. Current treatments for diabetics are inadequate because ...

Here, we characterize spatial distribution of the Golgi complex in human cells. In contrast to the prevailing view that the Golgi compactly surrounds the centrosome throughout interphase, we observe characteristic differences ...

Patients who have undergone radiation therapy for brain metastases often have latent lesions such as recurrent tumor or radiation necrosis. Differentiating these lesions in vivo is critical for providing adequate care, but ...

These studies tested the hypothesis that cell-extracellular matrix (ECM) interactions promote the maturation of invadopodia to fully functional structures. I demonstrate that invadopodia-associated ECM degradation is ...

The kidney's inherent complexity has made identifying cell-specific pathways challenging, particularly when temporally associating them with the dynamic pathophysiology of acute kidney injury (AKI). Here, we combine renal ...

Multicellular organisms adapt to the environment by sensing it and reacting to it through neuronal networks that are in place to transform a stimulus into a behavioral effect. A functional nervous system requires pruning ...

Instability phenomenon (cellular structure or multi-petal structure) and extinction behavior are studied in premixed tubular flames and non-premixed opposed tubular flames. A newly designed tubular burner that is capable ...