Browsing by Title
Now showing items 2384-2403 of 17412
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(2017-10-20)Department: Microbiology and ImmunologyCytomegalovirus (CMV) infection or latency reactivation is usually asymptomatic except in immune-suppressed hosts where it causes end-organ complications. CMV has also been proposed to drive cardiovascular disease in ...
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(2011-07-26)Department: PathologyCharacterization of fibrinogen-binding surface protein B (FbsB) in human blood coagulation and fibrinolysis, and of the NH2-terminal dipeptide of staphylocoagulase (SC) in conformational prothrombin activation are presented ...
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Characterization of functional human antibodies targeting henipavirus and flavivirus glycoproteins (2021-06-14)Department: Microbe-Host InteractionsThe henipaviruses Hendra (HeV) and Nipah (NiV), and the flavivirus yellow fever (YFV), pose massive global public health threats. No small molecule or antibody-based countermeasures are available to treat humans infected ...
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(2017-10-04)Department: NeuroscienceEpileptic encephalopathies (EEs) are a devastating group of severe childhood onset epilepsies with medication resistant seizures and poor developmental outcomes. Many EEs have a genetic etiology and are often associated ...
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(2008-03-13)Department: Biological SciencesDopamine plays key roles in many basic functions in the central nervous system. In order to study developmental and functional roles of dopaminergic cells in the zebrafish, we have examined a transgenic line of zebrafish ...
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(2018-06-11)Department: Biological SciencesDNA glycosylases preserve genome integrity and define the specificity of the base excision repair pathway for discreet, detrimental modifications. Bacterial HEAT-like repeat glycosylases AlkC and AlkD are specific for ...
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(2014-05-13)Department: Electrical EngineeringSingle event transients (SET) have become increasingly important to characterize since operating frequencies have surpassed 100 MHz. A common way to characterize SETs for a specific technology is to measure the range of ...
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(2008-12-06)Department: Electrical EngineeringRadiation-induced soft errors have become a key reliability issue for advanced semiconductor integrated circuits. With technology scaling, a large fraction of the observed soft failures are estimated to be related to latched ...
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(2012-04-26)Department: PharmacologyProteostasis is maintained by a complex network of genes and processes which includes core synthesis and degradation machineries as well as chemical and protein chaperones. Much of what is known about the function and ...
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(2023-08-15)Department: NeuroscienceThe insular cortex (IC) integrates sensory and interoceptive cues to inform downstream circuitry executing adaptive behavioral responses. The IC communicates with areas involved canonically in stress and motivation. IC ...
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(2011-09-01)Department: Molecular Physiology and BiophysicsRecent genome wide association (GWA) studies have linked single nucleotide polymorphisms (SNPs) in the G6PC2 gene with elevated fasting plasma glucose (FPG) and in the SLC30A8 gene with altered susceptibility to type 2 ...
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(2015-03-27)Department: Cell and Developmental BiologyThe intestinal epithelium is a continuously renewing tissue. This rapid renewal is fueled by stem cells that reside in the base of the crypts of Lieberkühn, the functional unit of the intestinal epithelium. The identity ...
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(2014-03-31)Department: Chemical EngineeringProduction of high-purity oxygen from air by pressure-swing adsorption (PSA) is of interest for a variety of applications. One recognized area for which this technology could be particularly useful is the development of ...
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(Vanderbilt University. Writing Studio, 2009-03-22)
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(2008-07-17)Department: PharmacologyInvestigating genetic forms of epilepsy allows for improved understanding of epilepsy pathophysiology in general. Mutations in voltage-gated sodium channels are a frequent cause of genetic forms of epilepsy. First we ...
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(2014-12-22)Department: ChemistryThe work presented here is the first of its kind where nanocrystal-based photovoltaics are characterized by directly imaging the electronic properties and correlating them to the structure of the sample. Through electron ...
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(2018-08-31)Department: Molecular Physiology and BiophysicsStress is a precipitating agent in neuropsychiatric disease and initiates relapse to drug-seeking behavior in addicted patients. Targeting the stress system in protracted abstinence from drugs of abuse with anxiolytics may ...
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(2010-08-04)Department: Biological SciencesA systematic Drosophila forward genetic screen for photoreceptor synaptic transmission mutants identified no-on-and-no-off transient C (nonC) based on loss of retinal synaptic responses to light stimulation. The cloned ...
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(2021-12-06)Department: Electrical EngineeringDevice-level radiation-induced photocurrent measurements, for characterization purposes and use in radiation hardening by design (RHBD) techniques, have historically been performed through off-chip measurements of ...
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(2011-08-01)Department: ChemistryCharacterization of Post-Translationally Modified Peptides and Proteins Using Lanthanide-Based Labeling Strategies By Randi Gant-Branum Abstract: Numerous biological processes are regulated by the stoichiometry of protein ...