Browsing by Title
Now showing items 3693-3712 of 17412
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(2017-08-11)Department: Biomedical EngineeringBreast cancer is the most common cancer in women and the second highest cause of cancer related deaths among women in the United States. Most breast cancers are treated by some form of surgical intervention. Breast ...
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(2020-06-02)Department: ChemistryHere in, we describe the optimization of high-affinity, choline up-take transporter (CHT) antagonist, ML352, to improved in vivo tool compound, VU6001221. VU6001221, a potent and selective CHT inhibitor with significantly ...
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(2021-05-11)Department: Biomedical EngineeringLoss of parathyroid function (hypoparathyroidism) is an unintended consequence of endocrine neck surgeries. This leads to an inability of the patient to maintain healthy levels of blood calcium, as the parathyroid glands ...
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(2016-04-15)Department: Biomedical EngineeringThe inability to identify the parathyroid glands is a significant challenge during endocrine procedures. Successful parathyroid and thyroid surgeries require careful resection of diseased tissue and preservation of normal ...
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(2018-10-30)Department: PhysicsOver the last few decades the capabilities of atomic-resolution imaging techniques such as Scanning-Transmission-Electron-Microscopy (STEM) have greatly increased. The data acquisition rate of modern of atomic-resolution ...
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(Childhood Obesity, 2020)To develop and test brief nutrition and physical activity screening questions for children ages 2–11 years that could be used as a pragmatic screening tool to tailor counseling, track behavior change, and improve population ...
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(2021-08-13)Department: ChemistryBiohybrid solar cells utilizing the plant protein complex Photosystem I (PSI) as the key photoactive ingredient are studied for their ability to reduce the cost and environmental impacts of solar energy harvesting technologies. ...
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(2004-12-01)Department: PsychologyIn a sample of 515 children (grades 2, 4, and 6), we examined parenting and negative life events as predictors of depressive cognitions, specifically depressogenic attributional style, depressive cognitive schemas, and low ...
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(2012-03-31)Department: PsychologyThe link between the experience of peer victimization (PV) and future psychological maladjustment, particularly depressive symptoms, has been consistently documented; however, little is known about intermediary cognitive ...
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(2009-12-23)Department: Biomedical EngineeringSkin cancer is the most common cancer in the United States, with an incidence rate that continues to rise. Fortunately, it can be highly curable if detected at an early stage. Best clinical practices require physicians to ...
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(2023-12)Resultant is a modern professional services consulting firm that seeks to define, aggregate, and assess the knowledge, skills, attributes, and other characteristics (KSAOs) of its Professional Services employees, including ...
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(2007-04-17)Department: Environmental EngineeringThis dissertation details the development of a consequence management system for water utilities, which determines the optimal operational response to a contamination event in a water distribution network. In order to ...
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(2021-01-05)Department: Civil EngineeringThis dissertation presents development of constitutive relations for progressive damage analysis of laminated composites and efficient computational implementation of a multiscale computational framework. All the numerical ...
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Development of Decision Support Tools for Water Energy Food Infrastructure Management of Sri Lanka (2020-01-17)Department: Environmental EngineeringThe energy and food sectors of the economy heavily rely on water resources. All nations face challenges of meeting increasing demand for water, food, and energy due to limited and uncertain resources, complex multisector ...
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(2017-07-20)Department: ChemistryPolymeric nanoparticles have historically been shown to be valuable tools for the solubilization and delivery of small molecule hydrophobic drugs. However, most systems do not address obstacles associated with off-target ...
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(2021-07-15)Department: ChemistryMalaria is a lethal infectious disease which is estimated to cause 229,000,000 cases worldwide, with 409,000 deaths. In this work, two methods are explored to enhance the efficacy and utility of malaria control and elimination ...
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(2023-08-22)Department: Chemical & Physical BiologyComputational structural biology tools are applied to many different systems to answer questions about how protein sequence and protein environment impacts the structure and function of a protein. These protein structure ...
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(2023-03-17)Department: Mechanical EngineeringSince its invention over 30 years ago, friction stir welding (FSW) has matured into a capable and versatile joining method for many materials and applications. The process enables the assembly of advanced materials that ...
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Development of hemodynamic targeted theranostic nanoparticles for the prevention of atherosclerosis (2015-03-20)Department: Biomedical EngineeringIn regions of the circulation where vessels are straight and unbranched, blood flow is laminar and unidirectional. In contrast, at sites of curvature, branch points and regions distal to stenoses blood flow becomes disturbed. ...
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Development of high throughput, mammalian cell-based metabolic rate assays for screening compounds (2005-02-21)Department: Chemical EngineeringFunctional characterization of diseased cellular metabolic state is necessary to complement current methods of in vitro toxicity testing. This dissertation focused on development of high throughput assays in 24- and 96-well ...