Browsing by Title
Now showing items 3702-3721 of 17412
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(2009-12-23)Department: Biomedical EngineeringSkin cancer is the most common cancer in the United States, with an incidence rate that continues to rise. Fortunately, it can be highly curable if detected at an early stage. Best clinical practices require physicians to ...
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(2023-12)Resultant is a modern professional services consulting firm that seeks to define, aggregate, and assess the knowledge, skills, attributes, and other characteristics (KSAOs) of its Professional Services employees, including ...
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(2007-04-17)Department: Environmental EngineeringThis dissertation details the development of a consequence management system for water utilities, which determines the optimal operational response to a contamination event in a water distribution network. In order to ...
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(2021-01-05)Department: Civil EngineeringThis dissertation presents development of constitutive relations for progressive damage analysis of laminated composites and efficient computational implementation of a multiscale computational framework. All the numerical ...
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Development of Decision Support Tools for Water Energy Food Infrastructure Management of Sri Lanka (2020-01-17)Department: Environmental EngineeringThe energy and food sectors of the economy heavily rely on water resources. All nations face challenges of meeting increasing demand for water, food, and energy due to limited and uncertain resources, complex multisector ...
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(2017-07-20)Department: ChemistryPolymeric nanoparticles have historically been shown to be valuable tools for the solubilization and delivery of small molecule hydrophobic drugs. However, most systems do not address obstacles associated with off-target ...
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(2021-07-15)Department: ChemistryMalaria is a lethal infectious disease which is estimated to cause 229,000,000 cases worldwide, with 409,000 deaths. In this work, two methods are explored to enhance the efficacy and utility of malaria control and elimination ...
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(2023-08-22)Department: Chemical & Physical BiologyComputational structural biology tools are applied to many different systems to answer questions about how protein sequence and protein environment impacts the structure and function of a protein. These protein structure ...
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(2023-03-17)Department: Mechanical EngineeringSince its invention over 30 years ago, friction stir welding (FSW) has matured into a capable and versatile joining method for many materials and applications. The process enables the assembly of advanced materials that ...
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Development of hemodynamic targeted theranostic nanoparticles for the prevention of atherosclerosis (2015-03-20)Department: Biomedical EngineeringIn regions of the circulation where vessels are straight and unbranched, blood flow is laminar and unidirectional. In contrast, at sites of curvature, branch points and regions distal to stenoses blood flow becomes disturbed. ...
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Development of high throughput, mammalian cell-based metabolic rate assays for screening compounds (2005-02-21)Department: Chemical EngineeringFunctional characterization of diseased cellular metabolic state is necessary to complement current methods of in vitro toxicity testing. This dissertation focused on development of high throughput assays in 24- and 96-well ...
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(2009-03-12)Department: PhysicsThe primary purpose of this thesis is to detail recent progress in the development of high-brightness cathodes for use in beam driven radiation sources. In particular, diamond field-emitter arrays (DFEA) are discussed and ...
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(2016-03-11)Department: ChemistrySystems biology greatly enhances the study of complex biological processes by expanding on reductionist approaches that have traditionally focused on individual biological components (i.e. glycomics). Systems biology ...
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(2022-10-10)Department: Biomedical EngineeringA broad range of surgical procedures involve working in areas proximal to vital nerves and neural structures. Currently, surgeons rely on their experience, anatomical knowledge, and visual assessment of the surgical field ...
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Development of methods for docking and designing small molecules within the Rosetta code framework (2012-10-15)Department: Chemical and Physical BiologyStructure-based drug design is a key challenge for pharmaceutical chemists. By studying the structure of proteins bound to natural substrates, researchers can design small molecules which they predict will bind in a similar ...
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(2015-04-05)Department: Mechanical EngineeringMicrofluidic systems provide numerous features and advantages that make them well-suited for investigations of interesting phenomena in cell biology. Several microfluidic cell culture platforms were developed to probe cell ...
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(2008-04-07)Department: Biomedical EngineeringEarly detection of breast lesions with malignant potential plays an important role in patient prognosis and survival. While X-ray mammography is the current clinical standard for screening and detection, traditional ...
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(2017-02-03)Department: ChemistryG protein-gated inwardly rectifying potassium (GIRK) ion channels are part of a larger family of inwardly rectifying potassium channels (Kirs) that regulate diverse biological processes. Kirs regulate solute balance in the ...
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(2008-12-22)Department: ChemistryMultianalyte microphysiometry is a real-time method for evaluating cellular metabolism using the multianalyte microphysiometer (MAMP), an instrument capable of measuring extracellular changes in the flux rates of oxygen, ...
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(2008-08-05)Department: Electrical EngineeringCVD diamond is an excellent material for field emission with low electron affinity, robust mechanical and chemical properties, high thermal conductivity, and ability to withstand extreme temperature and radiation. However, ...