Browsing by Title
Now showing items 5959-5978 of 17412
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(Vanderbilt University. Dept. of History, 2012-04)
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(2020-01-17)Department: Computer ScienceIntraoperative soft tissue deformation, referred to as brain shift, compromises the application of current image-guided surgery navigation systems in neurosurgery. A computational model driven by sparse data has been ...
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(Columbia Theological Seminary, 2006)
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(2010-08-02)Department: Cell and Developmental BiologyThis project provides a detailed characterization of the CLASP-dependent microtubule array at the Golgi in terms of function and regulation. First, I briefly outline the process of MT nucleation at the Golgi and highlight ...
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(2011-07-29)Department: PharmacologyActivating transcription factor 4 (Atf4) is a leucine zip transcription factor. Atf4 mutant (Atf4-/-) mice show severe low bone mass and short stature phenotype. Atf4 is expressed in growth plate chondrocytes. Atf4-/- ...
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(Vanderbilt University. Peabody College, 2021)With the effect of globalization, English as lingua franca has been treated significantly important all over the world. Since 1982, Chinese students need to study English as their compulsory subject in school. Moreover, ...
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(Molecular Genetics & Genome Medicine, 2019-06)BackgroundEpidemiological studies consistently indicate that alcohol consumption is an independent risk factor for female breast cancer (BC). Although the aldehyde dehydrogenase 2 (ALDH2) polymorphism (rs671: Glu>Lys) has ...
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(2016-03-04)Department: Microbiology and ImmunologyClostridium sordellii infections cause gangrene and edema in humans and gastrointestinal infections in livestock. The two principle virulence factors, TcsH and TcsL, are highly homologous to C. difficile TcdA and TcdB, ...
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(2007-03-14)Department: Microbiology and ImmunologyProtein synthesis is a complex and poorly understood process that requires the concerted activity of ribosomes and a plethora of trans-acting protein factors. This dissertation used proteomic, biochemical, and functional ...
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(2004-12-12)Department: Microbiology and ImmunologyExperimental and epidemiological studies have suggested that the vacuolating cytotoxin (VacA) is an important H. pylori virulence factor that contributes to the development of peptic ulceration and gastric adenocarcinoma. ...
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(2023-03-29)Department: Cell & Developmental BiologyIn pancreatic beta cells, molecular motors use cytoskeletal polymers microtubules as tracks for intracellular transport of secretory insulin granules. Beta-cell microtubule network has a complex architecture, which allows ...
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(2014-03-29)Department: Cell and Developmental BiologyMicrotubule-associated proteins (MAPS) frequently influence microtubule (MT) dynamics and may also alter MT-dependent processes, such as protein trafficking. RASSF1A is a MAP that is frequently silenced in most human ...
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(2014-09-16)Department: BiochemistryCytochrome P450s are versatile biocatalysts that play crucial roles in many important biological processes. Functional annotation of orphan P450 enzymes is the focus of this work. Catalytic activities of orphan human P450 ...
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(2020-11-03)Department: NeuroscienceAMPA receptors (AMPAR) are key mediators of fast excitatory neurotransmission within the brain. The functional identity of AMPAR at the synapses strongly contributes to molecular mechanisms of learning and memory. At the ...
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(2012-05-25)Department: PharmacologyMutations in inhibitory GABAA receptor γ2 subunit gene, GABRG2, have been associated with genetic epilepsy syndromes including childhood absence epilepsy (CAE), pure febrile seizures (FS), generalized epilepsy with febrile ...
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(2013-11-18)Department: Biological SciencesThis dissertation is concerned with the expression patterns, functionality and mechanisms of disease vector mosquito odorant receptors. The principal afrotropical vector for malaria, Anopheles gambiae, discriminates human ...
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(2022-05-09)Department: NeuroscienceThis dissertation work comprises a functional characterization of R294X and representative C-terminal stop loss MECP2 mutations that cause Rett syndrome (RTT) in people. In Chapter 2, we show that RTT-like phenotypes induced ...
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(2022-06-14)Department: Microbe-Host InteractionsGram-negative bacteria are frequently opportunistic pathogens that cause significant morbidity and mortality in humans. Escherichia coli and Klebsiella pneumoniae are two common Gram-negative pathogens that often acquire ...
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(2020-07-20)Department: Special EducationChildren with intellectual and developmental disabilities (IDD) frequently engage in escape-maintained problem behavior, which can limit their access to academic instruction and lead to placement in more restrictive ...
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(2006-10-06)Department: Molecular BiologyThis project was concerned with the functional components of mammalian DNA replication origins and how the misuse of a start site for DNA replication at the FMR1 locus might contribute to human Fragile X Syndrome. In ...