Browsing by Title
Now showing items 7332-7351 of 17412
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(2017-05-26)Department: Human GeneticsLung cancer is classified into two main types: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC has several subtypes, but the two most commonly occurring subtypes are lung adenocarcinoma (LUAD) ...
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(2006-04-18)Department: Molecular Physiology and BiophysicsMultiple sclerosis (MS) is a debilitating neuroimmunological and neuro-degenerative disease. Despite substantial evidence for polygenic inheritance, the MHC is the only region that clearly and consistently demonstrates ...
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(2022-11-19)Department: Biomedical EngineeringThe inflammatory response within the brain and spinal cord is a key biological response to disease, infection, and injury. Chronic pain and blast-induced traumatic brain injury (bTBI) are negatively impacted by the role ...
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(2022-01-14)Department: Civil EngineeringThe COVID-19 pandemic has left no sector of society untouched since first emerging in December 2019. Transportation, as one such sector, has been dramatically impacted. The switch to telecommuting completely changed the ...
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(2013-07-11)Department: Cell and Developmental BiologyNeurodegenerative diseases are characterized by inappropriate death of distinct neuronal populations. Although symptoms vary, these diseases share pathogenic features such as age-dependent onset and progressive death of ...
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(2022-03-29)Department: Cell & Developmental BiologyThe microtubule network in cells continuously remodels to facilitate its vital functions in cell division, cell motility and intracellular transport. Organization of the microtubule network is enabled by regulation of the ...
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(2011-12-01)Department: PsychologyThis dissertation takes a detailed look at two seemingly well-established procedures in Monte Carlo research. Part I closely examines the 3rd and 5th order polynomial transforms and the g-and-h distribution, all designed ...
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(2016-09-22)Department: Biomedical EngineeringMagnetization transfer (MT) imaging has emerged as a viable alternative to conventional structural MRI indices. It has been shown to be remarkably sensitive to changes in myelin associated with pathologies such as multiple ...
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(2023-03-14)Department: Chemical & Physical BiologyMicrotubules and actin filaments coordinate to remodel the cytoskeleton to facilitate proper cell migration. The coordination between microtubules and actin filaments are regulated by 1) chemical signals and 2) physical ...
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(2018-07-06)Department: Earth and Environmental SciencesUngulates regulate important processes within their ecosystems, however their impact on nitrogen cycling remains unclear, and likely ecosystem and soil-specific. Much of the work examining the relationship has been in ...
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(2014-07-16)Department: PharmacologySynaptic transmission is characterized by exocytotic events which mediate the release of chemical transmitters to facilitate neuronal communication. Inhibitory presynaptic GPCRs act as feedback regulators limiting transmitter ...
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(2020-05-19)Department: NeuroscienceExcitatory signaling mediated by N-methyl-d-aspartate receptors (NMDARs) has been shown to regulate mood disorders. However, current treatments targeting NMDAR subtypes have shown limited success in treating patients, ...
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(2023-11-16)Department: Cell & Developmental BiologyActin-based protrusions are found on the surface of all eukaryotic cells, where they support diverse biological activities essential for life. Models of protrusion growth hypothesize that actin filament assembly provides ...
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(2017-05-26)Department: PharmacologyObsessive-compulsive disorder (OCD) is a chronic, disabling condition with inadequate treatment options that leave most patients with substantial residual symptoms. Structural, neurochemical, and behavioral findings point ...
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(2007-12-06)Department: Biological SciencesIn most eukaryotes, telomere length is maintained by telomerase, a ribonucleoprotein that adds TG-rich telomeric repeats de novo to chromosome ends. Telomeric binding proteins (for example, Rap1p) affect telomere length ...
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(2013-12-09)Department: Cell and Developmental BiologyDuring liver development, precise signaling is required to direct cell fate decisions and architectural establishment. It is hypothesized that the same signaling pathways are important in directing liver regeneration. To ...
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(Royal Society Open Science, 2019-10)The influential triple-code model of number representation proposed that there are three distinct brain regions for three different numerical representations: verbal words, visual digits and abstract magnitudes. It was ...
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(2009-01-15)Department: Biomedical EngineeringDiffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) technique that provides information about the organization and structural integrity of tissue. It has become an increasingly popular tool for investigation ...
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(2010-12-07)Department: Human GeneticsNeither genome size nor gene number is indicative of organism complexity. Complex regulation of genes within a genome likely contributes to organism complexity. Coordinate regulation of genes through shared cis regulatory ...
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(2007-04-04)Department: Molecular Physiology and BiophysicsTFIID is a multi-subunit protein complex that regulates activation of gene transcription. The coactivator model proposes that a given transcription factor activates transcription of its target gene by recruiting TFIID to ...